肝脏局灶性病变的超声造影定量分析  

Application of contrast-enhanced ultrasound in focal liver lesions by quantitative analysis

作　　者：何志容[1] 吴小利[1] 彭亚琼[1] 肖海燕[1] 邹密密 张璇[1] 况里杉[2] 殷军[1] 

机构地区：[1]重庆市涪陵中心医院超声科,408000 [2]重庆市涪陵中心医院呼吸科,408000

出　　处：《重庆医学》2016年第26期3643-3645,3649,共4页Chongqing medicine

基　　金：重庆市卫计委医学科研计划研究项目(2012-2-434)

摘　　要：目的探讨超声造影定量分析在肝脏局灶性病变诊断与鉴别诊断中的应用价值。方法对153例肝脏局灶性病变患者(良性组67例,恶性组86例)行超声造影检查。利用SonoLiver软件分别对两组患者超声造影的动态过程进行分析,得到时间-强度曲线及动态血管模式曲线(DVP)。分析两组局灶性病变的动态血流灌注特点,计算出两组局灶性病变的超声造影定量分析参数:峰值强度(IMAX%)、上升时间(RT)、达峰时间(TTP)、平均渡越时间(MTT),同时计算出上升支斜率与1/2下降支斜率,然后进行统计学分析。结果良性组、恶性组间的血流灌注模式不同,定量分析参数亦有差异:良性组与恶性组的IMAX%、RT、TTP与周围肝组织比较差异有统计学意义(P<0.05);良性组与恶性组间的RT[(13.77±8.11)s和(8.95±4.73)s],MTT[(74.79±73.40)s和(40.75±60.91)s]与1/2下降支斜率[(8.62±13.56)和(43.56±81.42)],差异均有统计学意义(P<0.01),IMAX%差异没有统计学意义(P>0.05)。结论超声造影定量分析可以对肝脏局灶性病变的诊断与鉴别诊断提供较客观的依据,具有一定的临床应用价值。Objective To evaluate the application value of ultrasonic imaging quantitative analysis in the diagnosis and differ- ent diagnosis of focal liver lesions. Methods A total of 153 patients（67cases in benign group,86cases in malignant group） who suf- fered from focal liver lesions were examined by Contrast-enhanced ultrasonography （CEUS）. SonoLiver software was used to ana- lyse the dynamical process of the CEUS, then the time intensity curve and dynamic vascular pattern curve was obtained. The focal lesions and dynamic blood perfusion characteristics of two groups were analyzed,and the focal lesions of ultrasonic imaging quanti- tative analysis parameters of the two groups were calculated, including： the result of maximum intensity （IMAX%）, the rise time （RT） ,time to peak （TTP）,mean transit time （determined by MTTT）,and the slope of rise and 1/2 slope of down was calculated, then the statistical analysis was carried. Results The characteristics of flow infusion in these two groups were different,quantita- tive analysis parameters were also different：IMAX %, RT and TTP of benign and malignant group were significantly different com- pared with the surrounding liver tissue （P〈0.05 then P〈0. 01） ;differences of RT,MTT and 1/2 slope of down rate between be- nign and malignant groups were：（13. 77±8. 11） s,（8. 954±4. 73）; （74. 79±73.40） s, （40. 75±60.91） s;and（8. 62±13.56）, （43. 56±81.42）,and the differences were significant statistically （P〈0.01）, the differences of IMAX% has no statistical signifi- cance（P〈0.05）. Conclusion Ultrasonic imaging quantitative analysis has certain clinical value and can provide the objective basis for diagnosis and differential diagnosis of focal liver lesions.

关 键 词：超声检查 肝病 超声造影 肝脏局灶性病变 定量分析 

分 类 号：R445.1[医药卫生—影像医学与核医学]