舌下含服脱敏治疗对伴尘螨致敏慢性自发性荨麻疹患者的疗效观察  

Clinical effect of sublingual immunotherapy on chronic spontaneous urticaria with dust mite sensitization

作　　者：唐政[1] 瞿任 袁群霞[1] 张志梅[1] 

机构地区：[1]重庆市合川区人民医院皮肤科,401520

出　　处：《重庆医学》2016年第26期3650-3651,共2页Chongqing medicine

基　　金：重庆市合川区科委课题资助(2014014)

摘　　要：目的评价尘螨变应原舌下含服脱敏治疗对伴尘螨致敏慢性自发性荨麻疹的疗效。方法将98例伴有尘螨变应原皮肤点刺阳性的慢性自发性荨麻疹患者分为脱敏治疗组和常规治疗组。两组均给予口服盐酸左西替利嗪片并逐渐减量;脱敏治疗组同时接受舌下含服脱敏治疗,在治疗开始前及治疗后的第6、12个月评价所有患者荨麻疹疾病严重程度(UAS)和当月盐酸左西替利嗪片的总服用量。结果脱敏治疗组和常规治疗组在治疗后第6、12个月时的UAS均显著低于治疗前指标评分(P<0.01),且脱敏治疗组治疗在第6、12个月时的左西替利嗪片月平均服用量均显著低于常规治疗组(P<0.05)。结论舌下含服脱敏治疗联合抗组胺药治疗可有效改善伴尘螨致敏慢性自发性荨麻疹患者的症状并减少抗组胺药的服用量。Objective To evaluate the clinical effect of mite sublingual immunotherapy （SLIT） on chronic spontaneous urti-caria （CSU）. Methods The 98 patients with positive skin prick test to dust mite were randomly divided into two groups（SLIT group and routine treatmerLt group）. Both groups were received oral levocetirizine and the SLIT group was also received mite specif- ic immunotherapy. Urticaria activity scores （UAS） were evaluated at 6 and 12 months after treatment. Results The UASs of the sixth and twelfth month after treatment are significantly decreased c.ompared to those in baselines, and the total required levocetirizine in SLIT group was significantly less than that i,n routine treatment group. Conclusion Mite sublingual immunotherapy could im- prove symptoms and reduce required antihistaminic in patients with CSU.

关 键 词：荨麻疹 投药 舌下 脱敏疗法 尘螨致敏 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]