痰瘀同治法对不稳定型心绞痛疗效及血FINS、hs-CRP影响的临床观察  

Clinical Study of Phlegm and Blood Stasis Method on Unstable Angina Pectoris and the Influence on Blood FINS and Hs-CRP

作　　者：靳宏光 李俊[2] 李延吉[2] 郭家娟[1] 

机构地区：[1]长春中医药大学附属医院,吉林长春130021 [2]长春中医药大学,吉林长春130017

出　　处：《中国中医急症》2016年第9期1755-1757,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：吉林省中医药管理局项目(2014-ZC50)

摘　　要：目的探讨痰瘀同治法对冠心病不稳定型心绞痛的临床疗效。方法 72例患者随机分为治疗组和对照组各36例。对照组给予西医规范化治疗,治疗组在对照组基础上加服具有痰瘀同治功用的参红化浊通络方,疗程为2周。观察两组试验前后的心绞痛计分、西雅图心绞痛调查量表(SAQ)积分、血胰岛素(FINS)、超敏C反应蛋白(hs-CRP)变化,并进行统计分析。结果治疗后两组的心绞痛计分与治疗前比较均明显下降(均P<0.01),且治疗组优于对照组(P<0.05)。两组治疗前SAQ中5个维度积分组间比较差别不大(均P>0.05)。治疗后SAQ中5个维度积分较治疗前均明显增加(均P<0.05),且治疗组在活动受限程度、心绞痛发作情况及治疗满意度方面均优于对照组(均P<0.05)。治疗后,两组FINS、hs-CRP水平与治疗前比较均有不同程度改善(P<0.05或P<0.01),且治疗组均优于对照组(均P<0.05)。两组治疗过程中安全性指标监测均未见异常,亦未见明显不良反应。结论痰瘀同治法对冠心病不稳定型心绞痛具有良好疗效。Objective： To evaluate the clinical efficacy of phlegm and blood stasis in patients with unsta- ble angina pectoris. Methods： 72 patients were randomly divided into the treatment group and the control group,36 cases in each. The control group was given western medicine standardized treatment,while the treatment group was given Shenhong Huazhuo Tongluo Decoction. The treatment lasted for 2 weeks. The angina scores,Seattle Angina Questionnaire （SAQ） scores,blood insulin （FINS）,and high sensitive Creactive protein （hs-CRP） changes of two groups were observed before and after treatment,and then a statistical analysis was made. Results： After treatment,the scores of angina pectoris in the two groups decreased sig- nificantly compared with those before treatment（P〈0.01）;and the treatment group was better than the con- trol group （P〈0.05）. Before treatment,there was little difference between 5 dimensional integration in the SAQ （P〉0.05）. After treatment,5 dimension scores were significantly increased compared with those before treatment （P〈 0.05）. And the treatment group was better than the control group in the degree of activity limitation,as well as angina attack and treatment satisfaction（P〈0.05）. Before treatment,there was little dif- ference between the two groups in hs-CRP and FINS levels （P〉0.05）. After treatment,there were varying degrees of improvement in the levels of hs-CRP and FINS in the two groups compared with those before treatment（P〈0.05 or P〈0.01）,and the treatment group were better than the control group（P〈 0.05）. In the treatment process,there were no abnormal safety indicators and no obvious adverse reactions found in either group. Conclusion： Phlegm and blood stasis method has a good curative effect on unstable angina pectoris.

关 键 词：不稳定型心绞痛 痰瘀同治 血胰岛素 超敏C反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]