戊型肝炎病毒衣壳蛋白及其中和表位的结构研究进展  

Structure studies on hepatitis E virus capsid protein and its underlying neutralization epitope

作　　者：郑明华[1] 王凯航[1] 李琼[1] 张晓[2] 李少伟[1,2] 夏宁邵[1,2] 

机构地区：[1]厦门大学生命科学学院/国家传染病诊断试剂与疫苗工程技术研究中心,厦门361102 [2]厦门大学公共卫生学院/分子疫苗学和分子诊断学国家重点实验室,厦门361102

出　　处：《中国人兽共患病学报》2016年第9期825-831,共7页Chinese Journal of Zoonoses

摘　　要：戊型肝炎是由戊型肝炎病毒(Hepatitis E virus,HEV)引起的病毒性肝炎,被证实为人兽共患病,该病症对免疫力低下人群和已有基础性肝病的患者的危害更为显著。戊肝病毒主要通过粪口途径传播,猪是其主要的天然宿主。近年来,关于戊肝病毒的衣壳蛋白及其表位结构的研究取得了重要的进展,对于戊肝病毒的病毒学研究和戊肝疫苗的机制探讨起着重要的指导意义。本文将综述HEV病毒衣壳蛋白的结构研究和中和表位的结构基础,着重说明戊肝病毒中和表位存在型特异性和型交叉两种特征,提示型交叉表位与人兽共患现象的关系。Hepatitis E virus （HEV） is a causative pathogen of hepatitis E,one of the major acute infectious diseases,which has been recently proved as a zoonosis with main virus reservoir in domestic pigs. The virus is mainly spread by fecal-oral route and it＇s more likely to infect the immunocompromised population and those who have suffered from liver disease. To date, there are numbers progress on the structure of hepatitis E virus eapsid proteins and their immune complex with neutralizing mono- clonal antibodies. These knowledge advances our understanding on the virology and immunology of hepatitis E virus,and subse- quently benefits for the research and development of hepatitis E vaccine. Here,we review the key points in regard to the structure determination and immunologically functional basis of hepatitis E virus capsid protein. The summarized advances might shed lights on the theoretical basis for genotype specificity,eross-genotype feature and their correlation to zoonotic hepatitis E disease.

关 键 词：戊型肝炎病毒 人兽共患 结构 中和表位 

分 类 号：R373.2[医药卫生—病原生物学]