2型糖尿病患者CTGF及25-羟维生素D与视网膜病变的相关性  

Correlation of connective tissue growth factor and 25-hydroxy vitamin D levels with retinopathy in type 2 diabetes

作　　者：韩改玲[1] 

机构地区：[1]秦皇岛市第一医院内分泌科,河北秦皇岛066000

出　　处：《现代医学》2016年第8期1064-1067,共4页Modern Medical Journal

摘　　要：目的:探讨2型糖尿病患者结缔组织生长因子(CTGF)及25-羟维生素D(25-OH-Vit D)水平与视网膜病变的相关性。方法:选择2型糖尿病患者420例,根据免散瞳眼底摄片结果将其分为无视网膜病变(NDR)组和视网膜病变(DR)组;DR组中轻度和中度非增殖期的患者为DR1组,增殖期和重度非增殖期的患者为DR2组。分析3组各项生理指标、CTGF及25-OH-Vit D水平与视网膜病变之间的相关性。结果:DR组糖尿病的病程显著长于NDR组(P<0.05),糖化血红蛋白(Hb A1c)、糖化血清白蛋白(GA)和CTGF水平显著高于NDR组(P<0.05),但25-OH-Vit D水平显著低于NDR组(P<0.05)。DR1组糖尿病的病程显著短于DR2组(P<0.05),Hb A1c、GA、CTGF和总胆固醇(TC)水平显著低于DR2组(P<0.05),但25-OH-Vit D水平显著高于DR2组(P<0.05)。Spearman相关分析显示病程、Hb A1c、GA、CTGF和低密度脂蛋白胆固醇(LDLC)水平与DR之间呈现正相关(P<0.05),而25-OH-Vit D与DR之间呈现负相关(P<0.05);Logistic回归分析结果显示,影响DR发生和病理程度的独立危险因素分别是病程、Hb A1c、25-OH-Vit和CTGF水平(P<0.05)。结论:糖尿病患者体内25-OH-Vit D水平下降与CTGF水平上升共同影响着DR的出现及其病理过程,检测25-OH-Vit D及CTGF水平有助于对患者DR病程进行预测。Objective： To explore the correlation of connective tissue growth factor（ CTGF） and 25-hydroxy vitamin D（ 25-OH-Vit D） levels with retinopathy in type 2 diabetic patients. Methods： Four hundred and twenty patients with type 2 diabetic retinopathy were selected. According to the camera fundus radiography results,the patients were divided into non-diabetic retinopathy（ NDR） group and diabetic retinopathy（ DR） group. Among them,patients with mild and moderate non proliferative retinopathy were DR1 group and patients with retinopathy of the proliferative phase and the severe non proliferative phase were DR2 group. The correlation between the physiological indexes,CTGF and 25-OH-Vit D levels of the three groups were analyzed and compared. Results： The duration of diabetes in group DR were significantly longer than that of group NDR（ P〈0. 05）,the levels of glycosylated hemoglobin（ Hb A1c）,glycosylated serum albumin（ GA） and CTGF were significantly higher than those in group NDR（ P〈0. 05）,but the level of 25-OH-Vit D was significantly lower than that in group NDR（ P〈0. 05）.The diabetes duration of DR1 group was significantly shorter than that in group DR2（ P〈0. 05）,Hb A1 c,GA,CTGF and total cholesterol（ TC） levels were significantly lower than those in group DR2（ P〈0. 05）,but the level of serum 25-OH-Vit D was significantly higher than that in DR2 group（ P〈0. 05）. Spearman correlation coefficient analysis showed that the course of disease,the levels of Hb A1 c,GA,CTGF and low density lipoprotein cholesterol（ LDL-C） were positively correlated with DR（ P〈0. 05）,while 25-OH-Vit D and DR were negatively correlated（ P〈0. 05）. Logistic regression analysis showed that the course of disease,Hb A1 c,25-OH-Vit and CTGF were the independent risk factors influencing occurrence and pathological degree of DR（ P〈0. 05）. Conclusions： The decrease of 25-OH-Vit D level and the rise of CTGF level in the patients with diabetes affect the appearanc

关 键 词：糖尿病视网膜病变 结缔组织生长因子 25-羟维生素D 

分 类 号：R587.1[医药卫生—内分泌]