北京市2005－2014年急性乙型肝炎发病特征及病例复核结果分析  

Epidemiological characteristics and vertification analysis for acute hepatitis B in Beijing, 2005-2014

作　　者：王怀[1] 高培[1] 陈维欣[1] 孙燕妮[1] 付茵[1] 吕敏[1] 白霜[1] 张卫[1] 庞星火[1] 吴疆[1] 

机构地区：[1]北京市疾病预防控制中心免疫预防所,100013

出　　处：《中华预防医学杂志》2016年第9期815-819,共5页Chinese Journal of Preventive Medicine

基　　金：国家科技重大专项（2012ZX10004-904、2012ZX10002001-003-003）;北京市科学技术委员会重大项目（D121100003912001）

摘　　要：目的分析北京市急性乙型肝炎发病特征，并对抽样地区急性乙型肝炎病例进行流行病学调查和实验室复核。方法以国家法定传染病信息报告系统（NNDRS）2005—2014年报告的北京市急性乙型肝炎病例为基础，分析北京市急性乙型肝炎发病特征。采用分层整群随机抽样方法，以NNDRS中2005—2011年乙型肝炎平均报告发病率为基础，对18个报告地区进行抽样，抽取其中6个地区2012—2014年报告的急性乙型肝炎病例，进行流行病学个案调查（430例），同时进行血清学检测（307例）。复核抽取的急性乙型肝炎病例，分析急性乙型肝炎报告质量并对2005—2014年北京市急性乙型肝炎发病率进行调整。结果流行病学调查显示，2012—2014年北京市NNDRS报告的急性乙型肝炎符合率为89.5%（385/430）；实验室检测显示，急性乙型肝炎符合率为92.2%（283/307）。综合流行病学调查及实验室检测，2012—2014年北京市NNDRS报告的急性乙型肝炎病例总符合率为82.5%。2005—2014年北京市急性乙型肝炎调整发病率从5.05/10万降至0.98/10万，15岁以下急性乙型肝炎调整发病率降为0。结论2005—2014年北京市急性乙型肝炎发病率呈现下降趋势并已处于较低水平，15岁以下人群无急性乙型肝炎病例。Objective To analyze epidemiological characteristics of acute hepatitis B（aHPB）in Beijing and to recheck epidemiology and laboratory results of aHPB cases in the sampling area.Methods We analyzed epidemiological characteristics of aHPB cases reported in National Notifiable Disease Reporting System（NNDRS）from 2005 to 2014 in Beijing, using a stratified cluster sampling method and based on the average reported incidence of hepatitis B from 2005 to 2011 in NNDRS, we projected 430 aHPB cases in the sampling area from 2012 to 2014, for which 307 received blood sample retesting. Inclusion criteria of aHPB cases were those living in Beijing more than 1 year, using name, sex, age, or identity card number as key fields to verify that they had not been previously reported in the database. Accuracy and adjusted aHPB incidence rate for 2005- 2014 in Beijing was analyzed by rechecking aHPB cases.Results Epidemiological survey showed that aHPB coincidence rate was 89.5%（385/430）in NNDRS from 2012 to 2014 in Beijing. Laboratory tests showed that the aHPB coincidence rate was 92.2%（283/307）. The total coincidence rate was 82.54%. The aHPB adjustment incidence rate dropped from 5.05/100 thousand in 2005 to 0.98/100 thousand in 2014 in Beijing. The aHPB adjustment incidence rate among residents younger than 15 years dropped to 0/100 thousand.Conclusion The incidence of aHPB in Beijing dropped to a low level from 2005 to 2014. There were no aHPB cases in residents younger than 15 years.

关 键 词：肝炎 乙型 血清学 流行特征 

分 类 号：R512.62[医药卫生—内科学]