阻塞性睡眠呼吸暂停综合征患者静息态下海马功能连接的fMRI研究  

Functional connectivity of the hippocampus in obstructive sleep apnea syndrome on resting state fMRI study

作　　者：李海军[1] 彭德昌[1] 王志明[1,2] 龚洪翰[1] 聂思 叶成龙[1] 聂晓[1] 陈立婷[1] 

机构地区：[1]南昌大学第一附属医院影像科,江西南昌330006 [2]南昌市洪都中医院放射科

出　　处：《实用放射学杂志》2016年第9期1335-1339,共5页Journal of Practical Radiology

基　　金：国家自然基金项目（81560285）;江西省科技支撑计划项目（20132BBG70061）;江西省自然科学基金项目（20132BAB205100）;江西省研究生创新专项基金项目（YC2015-S082）.

摘　　要：目的 采用种子点功能连接方法，分析阻塞性睡眠呼吸暂停综合征（OSAS）患者静息态下海马与全脑功能连接的改变，探索OSAS患者认知功能下降的神经生理机制。方法 40例OSAS患者及40例正常对照组（NC）进行静息态下脑功能磁共振成像（fMRI）数据采集。以左、右侧海马为种子点进行全脑的功能连接，采用两样本t检验比较组间功能连接差异。结果 与NC组比较，OSAS患者左侧海马与双侧楔前叶、额中回、前扣带回、中央前回及右侧后扣带回功能连接减低,而与双侧小脑后叶功能连接增高。OSAS患者右侧海马与双侧额中回、后扣带回、边缘叶及右侧楔前叶功能连接减低,而与左侧顶下小叶及右侧小脑后叶功能连接增高。结论 OSAS患者海马与多个脑区存在功能连接异常，可能是OSAS患者认知功能下降的神经机制。Objective To analyze the resting-state functional connectivity changes of the hippocarnpus with the whole brain in patients with obstructive sleep apnea syndrome （OSAS） ,and to explore neurophysiological mechanisms of cognitive impairment in patients with OSAS. Methods 40 patients with OSAS and 40 normal controls （NC） were underwent functional magnetic resonance imaging （fMRI） scans during resting state. ROI-based on the left and right of hippocampus, functional connectivity coefficients were calculated with the whole brain,and to compare group differences using the two sample t test. Results Compared with NC,functional connectivity of the left hippocampus in OSAS was significantly decreased on bilateral precuneus, the medial frontal gyrus, the anterior cingutates,the precentral gyrus,the right posterior cingutate,and was significantly increased on bilateral cerebellum posterior lobe. Functional connectivity of the right hippocampus in OSAS was found to be significantly decreased on bilateral middle frontal gyrus, the limbic lobe,the posterior cingulate and the right precuneus, and increased on the left inferior parietal lobe and right cerebellum posterior lobe. Conclusion There are abnormal function connection between the hipppocampus and multiple brain lobes in OSAS patients,which may be neurophysiological mechanisms of cognitive impairment in OSAS.

关 键 词：阻塞性睡眠呼吸暂停综合征 海马 功能连接 静息态功能磁共振成像 

分 类 号：R563.8[医药卫生—呼吸系统] R332.81[医药卫生—内科学]