赖氨酸改性聚乳酸/聚乙二醇共聚物的制备及表征  

Preparation and Characterization of L-Lysine Modified PLLA-PEG Copolymers

作　　者：王雪红[1] 陈智[1] 魏杰[1] 陈建定[1] 唐颂超[1] 

机构地区：[1]华东理工大学材料学院,上海200237

出　　处：《高分子材料科学与工程》2016年第9期1-6,共6页Polymer Materials Science & Engineering

基　　金：国家自然科学基金资助项目(51173041)

摘　　要：在丙交酯与聚乙二醇开环共聚的基础上进行了二次聚合，利用具有生物相容性的赖氨酸对聚乳酸/聚乙二醇低聚物进行改性，制备出了赖氨酸改性聚乳酸/聚乙二醇共聚物。通过红外光谱、核磁共振谱、X射线衍射分析仪、差示扫描量热仪、凝胶渗透色谱和接触角测量仪分析比较了聚乳酸、聚乳酸/聚乙二醇和赖氨酸改性聚乳酸/聚乙二醇3种聚合物之间存在的差异。结果表明，实验成功合成了赖氨酸改性聚乳酸/聚乙二醇共聚物；赖氨酸（L-lys）的引入使得共聚物的热焓（ΔH）和熔点（Tm）分别由纯PLLA的81.57 J/g和177.34 ℃降到46.02 J/g和151.34 ℃，有效地改善了分子链的柔性和结晶度；聚合物的数均相对分子质量（Mn）也由纯PLLA的7.7×10^4降到了3.2×10^4，且相对分子质量分布变宽，但亲水性却得到大幅提高，有望适用于组织工程领域。Based on ring opening copolymerization of L-lactide （L-LA） and polyethylene glycol 400 （PEG-400）, secondary polymerization was carried out using L-lysine with biocompatibility to prepare L-lysine modified poly（lactic acid）/poly（ethylene glycol） copolymers. Obvious differences of PLLA, PLLA-PEG copolymer and L-lysine modified PLLA-PEG copolymer were characterized by FT-IR, NMR, XRD, DSC, GPC and contact angle measurement analysis （CA）. The experimental results show that ΔH and Tm of L-lysine modified PLLA-PEG copolymer synthesized fall from 81.57 J/g and 177.34 ℃ of pure PLLA to 46.02 J/g and 151.34 ℃ respectively, which effectively improve the chain flexibility and crystallinity. In addition, number-average molecular weight （Mn） of the copolymer decreases gradually from by 7.7×10^4 of pure PLLA to 3.2×10^4, and its dispersivity （Mw/Mn） becomes wider, but the increase of CA makes the hydrophilic higher, which could expect to be applied in the field of tissue engineering.

关 键 词：聚乳酸 聚乙二醇 赖氨酸 共聚 

分 类 号：TQ316.61[化学工程—高聚物工业]