通阳化浊法对动脉粥样硬化大鼠VEGF、VEGFR和bFGF表达的影响  

Effect of Tong Yang Hua Zhuo Method on the Expression of VEGF,VEGFR and b FGF in Coronary Atherosclerosis Rats

作　　者：袁丁[1] 黄培红[1] 靳利利[1] 苏慧[1] 史振羽[1] 王清海[1] 袁利梅[1] 

机构地区：[1]广东省第二中医院,广东广州510095

出　　处：《中医学报》2016年第8期1124-1127,共4页Acta Chinese Medicine

摘　　要：目的:观察通阳化浊法对动脉粥样硬化大鼠血管内皮生长因子(vascular endothelial growth factor,VEGF)、血管内皮生长因子受体(vascular endothelial growth factor receptor,VEGFR)和碱性成纤维细胞生长因子(basic fibroblast growth factor,b FGF)表达的影响。方法:制备动脉粥样硬化大鼠模型,随机分为通阳宽胸颗粒组、辛伐他汀组、通阳宽胸颗粒+辛伐他汀组、模型组和空白对照组,给予相应药物治疗8周后,检测斑块面积和VEGF、VEGFR及b FGF的表达。结果:1与空白对照组比较,模型组的斑块面积、VEGF、VEGFR和b FGF表达均显著增高(P<0.05);2与模型组相比,所有药物治疗组的斑块面积、VEGF、VEGFR和b FGF表达均显著降低(P<0.05),通阳宽胸颗粒+辛伐他汀组降低更明显;3VEGF、VEGFR和b FGF表达与斑块面积正相关。结论:通阳化浊法可有效抑制动脉粥样硬化中VEGF、VEGFR和b FGF的表达、缩小斑块的面积,尤其是与他汀类药物结合时,效果更显著。Objective ： To explore the effects of Tong Yang Hua Zhuo method on the expression of VEGF, VEGFR and bFGF in coronary atherosclerosis rats;and to clear its therapy role in cardiovascular diseases. Methods：Preparation of atherosclerosis sclerosis rats were randomly divided into groups of Tongyang granule, simvastatin, Tongyang combined with simvastatin, model and control, given appropriate medication 8 weeks before analysis plaque area and VEGF, VEGFR and bFGF levels by immunohistochemical. Results ：①Compared with the control group, the plaque area, VEGF, VEGFR and bFGF levels were significantly increased in model group（ P 〈 0.05 ） ;②compared with the model group, the plaque area, VEGF, VEGFR and bFGF levels were significantly lower in all drug treatment group （P 〈 0.05 ）, especially in Tongyang combine simvastatin group;③VEGF, VEGFR and bFGF were correlated with plaque area. Conclusions：Tong Yang Hua Zhuo method can effectively inhibit the expression of VEGF, VEGFR and bFGF in atherosclerosis and reduce plaque area, especially when combined with a statin;the drug is worthy of further promotion.

关 键 词：通阳化浊法 动脉粥样硬化 血管内皮生长因子 血管内皮生长因子受体 碱性成纤维细胞生长因子 大鼠 中医药 

分 类 号：R285.5[医药卫生—中药学]