育阴潜阳方对高血压患者血管内皮功能的影响  

Effect of Nourishing Yin and Suppressing the Excessive Yang Prescription on Vascular Endothelial Function in Patients with Hypertension

作　　者：胡为斌 何延忠[2] 

机构地区：[1]滑县人民医院,河南滑县456400 [2]河南中医药大学第三附属医院,河南郑州450008

出　　处：《中医学报》2016年第8期1167-1170,共4页Acta Chinese Medicine

基　　金：河南省科技攻关重点项目(112101310200)

摘　　要：目的:探讨育阴潜阳方对高血压患者血管内皮功能的影响。方法:选取124例高血压病患者为研究对象,随机分为对照组及观察组,每组62例。两组均予抗血压、降血脂等对症西医治疗,观察组再予育阴潜阳方进行干预。观察两组治疗前后血液流变学改变情况,采用全自动生化分析仪检测;血管紧张素(Angiotensin,Ang)Ⅱ,采用放射免疫法测定;一氧化碳(NO),采用比色法测定;超敏C-反应蛋白((hypersensitive C-reactive protein,hs-CRP),采用双抗体夹心酶联免疫吸附试验检测;血管内皮功能测定,采用彩色超声心动仪进行测定血管内皮细胞依赖性舒张功能(FMD)及内皮细胞非依赖性舒张功能(GTN),以及治疗前后症状总积分。结果:观察组治疗后血浆黏度、血小板最大聚集率、纤维蛋白原水平均低于对照组,差异有统计学意义(P<0.05)。观察组治疗后AngⅡ、hs-CRP水平均低于对照组,而NO水平高于对照组,差异均有统计学意义(P<0.05)。两组治疗前后血管直径大小无明显变化(P>0.05);观察组治疗后FMD、GTN水平均高于对照组,差异有统计学意义(P<0.05)。观察组治疗后症状总积分明显低于对照组(P<0.01)。对照组有效率87.1%,观察组有效率96.7%,两组比较,差异有统计学意义(P<0.05)。结论:育阴潜阳方能有效改善阴虚阳亢型高血压患者血管内皮功能,提高临床疗效。Objective ：To investigate the effect of nourishing Yin and suppressing the excessive Yang prescription on the vascular endothelial function in patients with hypertension. Methods ：124 cases of hypertension patients were randomly divided into the control group and the observation group,62 cases in each group. The two groups were given anti blood pressure, lowering blood lipid and other symptomatic western medicine treatment, the observation group was additionally given nourishing Yin and suppressing the excessive Yang prescription. The blood rheology was observed before and after treatment in two groups, and the whole automatic biochemical analyzer was used to detect the blood theology; Angiotensin （Angiotensin, Ang） II, measured by radioimmunoassay; Carbon monoxide （NO） was measured by colorimetric method;High sensitive C-reactive protein （hs-CRP）, using double antibody sandwich enzyme linked immunosorbent assay;vascular endothelial function was measured by color Doppler echocardiography in the measurement of vascular endothelial cell dependent relaxing function （ FMD% ） and endotbelium independent relaxing function （ GTN% ） ; as well as the total score of symptoms before and after treatment. Results ： In the observation group after treatment, the plasma viscosity,the maximum aggregation rate of platelet, the average level of fibrinogen in raw water was lower than that in the control group,the difference was statistically significant （P 〈 0.05）. In the observation group after treatment Ang II, hs-CRP levels were lower than the control group, while the NO level was higher than the control group, the difference was statistically significant（P 〈0.05）. There was no significant difference in blood vessel diameter between the two groups before and after treatment,and there was no significant difference between the two groups （P 〉0.05） ;the observation group after treatment,FMD and GTN levels were higher than the control group, the difference was statistically significant （

关 键 词：高血压 育阴潜阳方 阴虚阳亢证 血管内皮功能 中医药治疗 

分 类 号：R259.441[医药卫生—中西医结合]