In Vitro Evaluation of the Feasibility of Commercial Zn Alloys as Biodegradable Metals  

作　　者：C.Wang H.T.Yang X.Li Y.F.Zheng 

机构地区：[1]Department of Interventional Radiology and Vascular Surgery, Peking University Third Hospital [2]Department of Materials Science and Engineering, College of Engineering, Peking University

出　　处：《Journal of Materials Science & Technology》2016年第9期909-918,共10页材料科学技术（英文版）

基　　金：supported by the National Basic Research Program of China (973 Program) (Grant Nos. 2012CB619102 and 012CB619100);National Science Fund for Distinguished Young Scholars (Grant No. 51225101);National Natural Science Foundation of China (Grant Nos. 51431002 and 31170909);the NSFC/RGC Joint Research Scheme (Grant No. 51361165101);State Key Laboratory for Mechanical Behavior of Materials (Grant No. 20141615);Beijing Municipal Science and Technology Project (No. Z141100002814008)

摘　　要：In this work, three widely used commercial Zn alloys （ZA4-1, ZA4-3, ZA6-1 ） were purchased and pre- pared by hot extrusion at 200℃. The microstructure, mechanical properties, corrosion behaviors, biocompatibility and hemocompatibility of Zn alloys were studied with pure Zn as control, Commercial Zn alloys demonstrated increased strength and superb elongation compared with pure Zn. Accelerated corrosion rates and uniform corrosion morphologies were observed in terms of commercial Zn alloys due to galvanic effects between Zn matrix and α-Al phases. 100% extracts of ZA4-1 and ZA6-1 alloys showed mild cytotoxicity while 50% extracts of all samples displayed good biocompatibility. Retardant cell cycle and inhibited stress fibers expression were observed induced by high concentration of Zn^2＋ releasing during corrosion. The hemolysis ratios of Zn alloys were lower than 1% while the adhered platelets showed slightly activated morphologies. In general, commercial Zn alloys possess promising mechanical properties, appropriate corrosion rates, significantly improved biocompatibility and good hemocompatibility in comparison to pure Zn. It is feasible to develop biodegradable metals based on commercial Zn alloys.In this work, three widely used commercial Zn alloys （ZA4-1, ZA4-3, ZA6-1 ） were purchased and pre- pared by hot extrusion at 200℃. The microstructure, mechanical properties, corrosion behaviors, biocompatibility and hemocompatibility of Zn alloys were studied with pure Zn as control, Commercial Zn alloys demonstrated increased strength and superb elongation compared with pure Zn. Accelerated corrosion rates and uniform corrosion morphologies were observed in terms of commercial Zn alloys due to galvanic effects between Zn matrix and α-Al phases. 100% extracts of ZA4-1 and ZA6-1 alloys showed mild cytotoxicity while 50% extracts of all samples displayed good biocompatibility. Retardant cell cycle and inhibited stress fibers expression were observed induced by high concentration of Zn^2＋ releasing during corrosion. The hemolysis ratios of Zn alloys were lower than 1% while the adhered platelets showed slightly activated morphologies. In general, commercial Zn alloys possess promising mechanical properties, appropriate corrosion rates, significantly improved biocompatibility and good hemocompatibility in comparison to pure Zn. It is feasible to develop biodegradable metals based on commercial Zn alloys.

关 键 词：Commercial Zn alloys Biodegradable metals Mechanical properties Corrosion behaviors Cytotoxicity Hemocompatibility 

分 类 号：TG146.13[一般工业技术—材料科学与工程] TQ323.8[金属学及工艺—金属材料]