Processing of a Novel Zn Alloy Micro-Tube for Biodegradable Vascular Stent Application  

作　　者：Chang Wang Zhentao Yu Yajun Cui Yafeng Zhang Sen Yu Gongqi Qu Haibo Gong 

机构地区：[1]Northwest Institute for Nonferrous Metal Research,Xi'an 710016,China [2]Xi'an University of Architecture and Technology,Xi'an 710055,China [3]Xi'an Advanced Medical Technology Co.,Ltd,,Xi'an 710077,China

出　　处：《Journal of Materials Science & Technology》2016年第9期925-929,共5页材料科学技术（英文版）

基　　金：supported by the National Basic Research Program of China(973 Program)(Grant No.2012CB619102);the National Science Foundation of China(Grant No.31400821);the innovation fund of Western Metal Materials(Grant No.XBCL-3-14)

摘　　要：In recent years, zinc based alloys as a new biodegradable metal material aroused intensive interests. However, the processing of Zn alloys micro-tubes （named slender-diameter and thin-walled tubes） is very difficult due to their HCP crystal structure and unfavorable mechanical properties. This study aimed to develop a novel technique to produce micro-tube of Zn alloy with good performance for biodegrad- able vascular stent application. In the present work, a processing method that combined drilling, cold rolling and optimized drawing was proposed to produce the novel Zn-5Mg-1Fe （wt%） alloy micro- tubes. The micro-tube with outer diameter of 2.5 mm and thickness of 130 μm was fabricated by this method and its dimension errors are within 10 μm. The micro-tube exhibits a fine and homogeneous microstructure, and the ultimate tensile strength and ductility are more than 220 MPa and 20% respectively. In addition, the micro-tube and stents of Zn alloy exhibit superior in vitro corrosion and expansion performance. It could be concluded that the novel Zn alloy micro-tube fabricated by above method might be a promising candidate material for biodegradable stent.In recent years, zinc based alloys as a new biodegradable metal material aroused intensive interests. However, the processing of Zn alloys micro-tubes （named slender-diameter and thin-walled tubes） is very difficult due to their HCP crystal structure and unfavorable mechanical properties. This study aimed to develop a novel technique to produce micro-tube of Zn alloy with good performance for biodegrad- able vascular stent application. In the present work, a processing method that combined drilling, cold rolling and optimized drawing was proposed to produce the novel Zn-5Mg-1Fe （wt%） alloy micro- tubes. The micro-tube with outer diameter of 2.5 mm and thickness of 130 μm was fabricated by this method and its dimension errors are within 10 μm. The micro-tube exhibits a fine and homogeneous microstructure, and the ultimate tensile strength and ductility are more than 220 MPa and 20% respectively. In addition, the micro-tube and stents of Zn alloy exhibit superior in vitro corrosion and expansion performance. It could be concluded that the novel Zn alloy micro-tube fabricated by above method might be a promising candidate material for biodegradable stent.

关 键 词：Zn alloy Micro-tube Biodegradable stent Mechanical properties Dimensional accuracy In vitro corrosion performance 

分 类 号：R318.11[医药卫生—生物医学工程]