干扰素对丙型病毒肝炎的治疗效果观察  

Therapeutic effect of interferon on hepatitis C

作　　者：邓雪辉 

机构地区：[1]江西省抚州市南城县人民医院内三科,江西南城344700

出　　处：《中国当代医药》2016年第25期144-146,共3页China Modern Medicine

摘　　要：目的探讨干扰素（安福隆）治疗丙型病毒肝炎（丙肝）的效果。方法选取2013年7月~2014年7月在我院进行诊治的50例丙肝患者,随机将其分为治疗组和对照组,每组各25例。对照组患者采用常规治疗,治疗组患者在常规治疗的基础上加用安福隆及利巴韦林进行治疗,比较两组患者的血清丙氨酸氨基转移酶（ALT）及丙型肝炎病毒（HCV）标志变化,分析其治疗效果。结果治疗结束,两组患者的ALT复常率差异无统计学意义（P〉0.05）,治疗组患者HCV-RNA及抗HCV转阴率明显高于对照组（P〈0.01）。治疗后12个月后,治疗组的临床疗效明显优于对照组（P〈0.05）,ALT复常率、HCV-RNA及抗HCV转阴率均高于对照组（P〈0.05）。治疗组患者中有12例在治疗1周内出现流感样症状,经对症处理后症状消失,治疗效果未受到影响,未见其他明显的不良反应,不良反应发生率为48.0%。对照组患者未见明显不良反应,治疗组患者的不良反应发生率明显高于对照组（P〈0.01）。结论干扰素（安福隆）治疗丙肝,可以显著提高ALT复常率、HCV-RNA及抗HCV转阴率,在治疗的过程中,会出现流感样症状,但不会影响治疗效果。Objective To explore the curative effect of interferon in treatment of hepatitis C.Methods 50 patients with hepatitis C from July 2013 to July 2014 in our hospital,and were randomly divided into treatment group and control group,with each of 25 cases.Control group was treated by routine therapy,the treatment group was given interferon and ribavirin treatment patients on the basis of conventional treatment,two groups of patients with serum alanine aminotransferase（ALT） and hepatitis C virus（HCV） signs of change were compared,its therapeutic effect was analyzed.Results After treatment,the rate of two groups of patients after ALT often there was no significant difference（P〈0.05）,the treatment group patients with HCV RNA and HCV resistant overcast rate was significantly higher than that of control group（P〈0.01）.After 12 months after treatment,the effect in treatment group was obviously higher than that of control group（P〈0.05）;ALT compound rate,HCV RNA and HCV resistant rate of treatment group patients was higher than that in control group respectively（P〈0.05）.12 cases of treatment group patients in the treatment of influenza-like symptoms within 1 week,the symptom disappeared after symptomatic treatment,the treatment effect was not affected,and was no other obvious adverse reaction,the incidence of adverse reactions was 48.0%.Patients in control group did not see obvious adverse reactions.Incidence of adverse reactions in patients of treatment group was obviously higher than that of control group（P〈0.01）.Conclusion Interferon in the treatment of hepatitis C,can significantly improve the ALT compound rate,HCV RNA and HCV resistant,in the process of treatment,can appear flu-like symptoms,but does not affect the treatment effect.

关 键 词：干扰素 丙肝 血清丙氨酸氨基转移酶 丙型肝炎病毒 

分 类 号：R512.6[医药卫生—内科学]