十全大补丸对环孢菌素A肝毒性的作用  

Effects of Shiquandabu bolus on cyclosporinl induced hepatotoxicity in rats

作　　者：张黎明[1] 朱丽青[1] 吴秀华 

机构地区：[1]济南军区总医院,济南250031 [2]济南军区106医院

出　　处：《中国临床药理学与治疗学杂志》1998年第3期192-194,共3页

摘　　要：目的观察十全大补丸对环孢菌素A(CsA)所致大鼠肝毒性的作用。方法大鼠分为4组 :ⅠCsA组(50mg/kg) ,ⅡCsA +十全大补丸高剂量组(50mg/kg +0.6g/kg) ,ⅢCsA +大补丸低剂量组(50mg/kg+0.3g/kg) ,Ⅳ空白对照组(等量2 %羧甲基纤维素CMC)。灌胃给药 ,每日1次 ,连续7天后取血 ,测定血清谷丙转氨酶(GPT)、硷性磷酸酶(AKP)及血清超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽s_转移酶(GST)。取肝组织作病理检查。结果用药7天后 ,CsA +十全大补丸高、低剂量组 ,均有明显降低血清GPT、AKP的作用 ,与单用CsA相比 ,有显著性差异。各用药组SOD活力与对照组比都有所下降 ,差异显著 :但合并用药组与单用CsA组比 ,无显著性差异。各用药组GST活力与对照组比也有所下降 ,但无显著性差异 ;合并用药组MDA均高于对照组 ,单用CsA组低于对照组。结论十全大补丸对CsA所致大鼠肝毒性有保肝降酶作用 ,其抗氧化清除自由基作用不明显。Aim The effect of Shiquandabu bolus (SQDB), a preparation of traditional Chinese medicaine, on cycloporine (CsA) induced hepatotoxicity in rats was observed . Methods Wistar rats were separated into four groups: CsA(50 mg/kg), CsA(50 mg/kg)+SQDB(0.6 g/kg),CsA(50 mg/kg)+SQDB(0.3 g/kg) and normal saline (2% CMC_Na) were separately given to the rats(ig,qd) for seven days, and then the parameters about liver function, glutamic_pyruvic transaminase (GPT), alkaline phosphatase (AKP),superoxide dismutase (SOD), malondialdehyde (MDA) and glutathione s_trans_ferase(GST) in serum , were determined, and pathologieal changes of liver tissue were observed by light microscope . Results In the CsA group, the levels of GPT and AKP in serum were higher significantly, but in the SQDB groups lower than those in the normal.The levels of SOD and GST were decreased more significantly in the three drug groups than in the normal, but there was no significant difference in decrease between the SQDB and CsA groups. The levels of MDA in the two SQDB groups were higher but in the CsA group lower than in the normal. Conclusion SQDB has the effect of ferment reduction but no effect of clear anti_oxidation and removing free radicals on CsA hepatotoxicity in rats.

关 键 词：十全大补丸 孢菌素A 肝素性 动物实验 保肝降酶 

分 类 号：R285.5[医药卫生—中药学]