某院2014年药品不良反应报告回顾性分析  

Retrospective Analysis of Adverse Drug Reaction Reports in a Hospital During 2014

作　　者：白娟[1,2] 李龙[1,2] 宋融[3] 闫丹[2] 乔逸[2] 文爱东[2] 

机构地区：[1]陕西中医药大学药学院,陕西咸阳712046 [2]第四军医大学西京医院药剂科 [3]西安医学院

出　　处：《药物流行病学杂志》2016年第9期568-572,共5页Chinese Journal of Pharmacoepidemiology

摘　　要：目的：了解某院药品不良反应（ADR）发生特点，为临床安全用药提供参考。方法：采用回顾性分析方法对某院2014年上报的366份ADR报告进行统计分析。结果：发生ADR的患者年龄分布以51～60岁最多，女性（52．2％）多于男性（47．8％）；发生ADR的怀疑药物主要为抗肿瘤药物，其次为抗感染药物；ADR所累及器官以消化系统损害为主。366例ADR报告中，新的ADR5例，严重的ADR19例，新的和严重的ADR仅占总报告数的6．6％。关联性评价结果显示，评价为很可能的病例报告最多（237例），占总数的64．8％。结论：引起ADR的怀疑药物以抗肿瘤药物及抗感染药物为主，因此应该重视该类药物的管理，积极进行ADR监测，减少ADR的发生，促进临床用药安全。Objective：To study the characteristics of adverse drug reactions in a hospital, provide a reference for clinical rational drug use. nethods：A retrospective analysis of a hospital in 2014 reported 366 adverse reaction reports for statistical analysis. Results：ADR occurred in patients with age distribution up to 51-60 years old, females （52.2%） over- all than men （47.8%） ; A hospital adverse reactions of drugs, primarily for the anti-tumor drugs, followed by anti-infec- tives; for adverse reactions involving damage to the main organs in the digestive system. Within the 366 cases of ADR re- ports, the new ADR was 5 cases, 19 cases of severe ADR, new and severe ADR accounted for only 6.6% of the total num- ber of the report. The relevance evaluation result showed that the most likely case report （237 cases） was the most, which was 64.8% of the total. Conclusion ：Adverse reactions to anti-tumor drugs and anti-infectives, hence should pay attention to the management of these drugs, active drug monitoring, thereby reducing the incidence of adverse reactions, the promo- tion of rational drug use.

关 键 词：药品不良反应 回顾性分析 报告 监测 安全用药 

分 类 号：R951[医药卫生—药学]