重组人皮肤模型EpiSkin^(TM)在化学品皮肤腐蚀分类中的应用研究  

Application of reconstructed human epidermis model EpiSkin^(TM) in classification of chemical skin corrosion

作　　者：姚丽芳[1] 蒋伟[1] 陈相[1] 缪文彬[1] 赵锷 李楠 蔡臻子 

机构地区：[1]上海出入境检验检疫局工业品与原材料检测技术中心,上海200331 [2]欧莱雅中国研发和创新中心,上海201203

出　　处：《职业卫生与应急救援》2016年第4期282-284,共3页Occupational Health and Emergency Rescue

基　　金：国家质量监督检验检疫总局科技计划项目(编号:2016IK228)

摘　　要：目的为化学品皮肤腐蚀性分类提供有效可靠的体外替代检测方法。方法使用EpiSkin ^(TM)重组人皮肤模型,对已知分类类别的标准参考物以及未知分类类别的化学物质进行检测,评估其在化学品皮肤腐蚀性分类中的应用。结果标准参考物二氯乙酰氯分类为1A类,乙醛酸一水合物分类为1B/1C类,分类结果与已知分类一致。无磷转化膜为非腐蚀性物质,防腐剂为1B/1C类。结论 EpiSkin ^(TM)重组人皮肤模型测试方法适用于化学品腐蚀性分类评估。Objective To provide an effective and reliable in vitro evaluation method for skin corrosion induced by chemicals.Methods EpiSkin TM reconstructed human epidermis model was used to classify chemical substances with known classification categories and unknown classification categories,and to evaluate the applicability of EpiSkin TM in skin corrosion induced by chemicals.Results In corrosion test,dichloroacetyl chloride was identified as 1A,glyoxylic acid monohydrate was identified as1B/1C,which were consistent with the known classification.The other two unknown-classification substances were classified as non-corrosive and 1B/1C,respectively.Conclusion The in vitro testing method using EpiSkin TM reconstructed human epidermis model is suitable for classification and evaluation of skin corrosion induced by chemicals.

关 键 词：皮肤腐蚀 体外替代实验 重组人皮肤模型 EpiSkinTM 

分 类 号：R135.7[医药卫生—劳动卫生]