抗菌药物使用与鲍曼不动杆菌耐药率的相关性分析  

Correlation of antibiotic consumption and resistance of Acinetobacter baumannii

作　　者：郭桐宇 段宝京 李泽[1] 史国兵[1] 党大胜[1] 

机构地区：[1]沈阳军区总医院药学部临床药学室,沈阳110000 [2]沈阳药科大学生命科学与生物制药学院,沈阳110016 [3]河北省人民医院药学部,石家庄050051

出　　处：《中国抗生素杂志》2016年第9期710-717,共8页Chinese Journal of Antibiotics

摘　　要：目的探讨沈阳军区总医院(以下简称"该院")抗菌药物使用情况与鲍曼不动杆菌耐药率之间的相关性。方法回顾该院2011年1月至2015年9月每季度住院患者抗菌药物的使用情况及同期住院患者送检标本中分离的鲍曼不动杆菌对常用抗菌药物的耐药率,应用SPSS21.0统计软件进行数据分析。结果鲍曼不动杆菌对多种抗菌药物耐药率高,仅对米诺环素耐药率相对较低。一、二代头孢菌素类、喹诺酮类、β-内酰胺类/β-内酰胺类酶抑制剂用药频度为该院前3位。鲍曼不动杆菌对左氧氟沙星耐药率与半合成四环素类及甘氨酰环素类抗菌药物的用药频度呈高度负相关(r=-0.891,P=0.042)。结论鲍曼不动杆菌耐药率居高不下,其治疗方案的制定可根据地区或医院细菌检测数据经验选择抗菌药物,适当的抗菌药物品种更替也可降低鲍曼不动杆菌的耐药。Objective To investigate the relationship between antibiotic consumption and drug resistance of Acinetobacter baumannii in General Hospital of Shenyang Military Region. Methods The consumption of common antibiotics in hospitalized patients were collected from January 2011 to September 2015 quarterly. Clinical isolates of Acinetobacter baumannii from those patients were collected. Relationship between antibiotic consumption and resistance of Acinetobacter baumannii analysed by SPSS 21.0. Results The resistant rates of Acinetobacter baumannii isolated from inpatients were high. Consumption of cephalosporins, quinuolones and beta-lactams/beta-lactamases inhibitors were the first three places. There was a negative correlation between the resistant rate of Acinetobacter baumannii to levofloxacin and consumption of the semisynthesised tetracyclines and glycylcycline（r=-0.891, P=0.042）. Conclusion The high prevalence of resistant Acinetobacter baumannii strains should be paid more attention. The therapy of Acinetobacter baumannii could be decided by antibiotics bacterial detection data of regions or hospitals, appropriate antibiotics species replacement can also reduce resistance of Acinetobacter baumannii.

关 键 词：鲍曼不动杆菌 耐药性 抗菌药物 医院感染 

分 类 号：R978.1[医药卫生—药品]