国产左心室隔离装置治疗左心室壁瘤动物实验研究  

Domestic left ventricular partitioning device for the treatment of left ventricular aneurysm:an experimental study in animals

作　　者：朱天宇[1] 朱政斌[1] 丁风华[1] 梅奇峰 杜润[1] 朱劲舟[1] 张瑞岩[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院心内科,200025 [2]上海心瑞医疗科技有限公司

出　　处：《介入放射学杂志》2016年第9期803-809,共7页Journal of Interventional Radiology

基　　金：上海市科委课题项目(14441902302)

摘　　要：目的通过动物实验验证经导管植入国产左心室隔离装置(LVPD)Heartech治疗左心室壁瘤的效果。方法构建4头山羊左心室壁瘤模型,建模12周后植入Heartech LVPD,术后16周处死山羊并取出LVPD,扫描电镜观察其表面内皮细胞生长情况。建模前、建模后、LVPD植入前、植入后及植入16周复查时,左心室造影检测左心室收缩末容积(LVESV)、左心室舒张末容积(LVEDV)、左心室射血分数(LVEF)、每搏射血量(SV)、心输出量(CO)、机械效率(ME)等指标。结果 Heartech LVPD植入16周后检测数据与植入前相比,LVESV分别为(25.02±1.81)ml和(40.71±4.93)ml(P<0.01),LVEDV分别为(51.53±3.33)ml和(61.51±4.67)ml(P<0.01),LVEF分别为(50.13±2.99)%和(33.90±4.29)%(P<0.01),SV分别为(26.39±2.01)ml和(20.79±2.17)ml(P<0.01),CO分别为(3.54±0.38)L/min和(3.21±0.36)L/min(P<0.05),ME分别为(67.56±1.78)%和(48.88±5.07)%(P<0.01);LVPD表面内皮细胞生长情况良好。结论经导管植入国产Heartech LVPD治疗左心室壁瘤效果显著。Objective To evaluate the curative effect of Heartech, a domestic left ventricular partitioning device （LVPD）, in treating left ventricular aneurysm through animal experiment. Methods Left ventricular aneurysm model was established in 4 experimental goats, and 12 weeks after modeling Heartech LVPD was implanted in the goats. The goat models were sacrificed 16 weeks after the implantation, and Heartech LVPDs were taken out and sent for electron microscope scanning examination to observe the endothelial cell growth state on the surface of Heartech LVPD. Before and after the modeling, before and after the implantation of Heartech LVPD, as well as at 16 weeks after the implantation, left ventricular angiography was performed to determine the left ventficular end-systolic volume （LVESV）, left ventricular end-diastolic volume, left ventricular ejection fraction （LVEF）, stroke volume （SV）, cardiac output （CO）, mechanical efficiency （ME）, etc. Results At 16 weeks after HeartechLVPD implantation, the LVESV was increased from preoperative （25.02±1.81） ml to postoperative （40.71±4.93） ml （P〈0.01）, the LVEDV was increased from preoperative （51.53±3.33） ml to postoperative （61.51±4.67） ml （P〈0.01）, the LVEF was decreased from preoperative （50.13±2.99）% to postoperative （33.90±4.29）% （P〈0.O1）, the SV was decreased from preoperative （26.39±2.01） ml to postoperative （20.79±2.17） ml （P〈0.01）, the CO was decreased frompreoperative （3.54±0.38） L/min to postoperative （3.21±0.36） L/min （P〈0.05）, and the ME was decreased from preoperative （67.56±1.78））% to postoperative （48.88±5.07）% （P〈0.01）. On the surface of LVPD the endothelial growth was in good condition. Conclusion For the treatment of left ventrieular anenrysm, transcatheter implantation of domestic Hearteeh LVPD has excellent curative effect.

关 键 词：经皮心室重建术 左心室隔离装置 心力衰竭 左心室壁瘤 

分 类 号：R541[医药卫生—心血管疾病]