不同时点血浆脑钠肽及超敏C-反应蛋白水平与老年非ST段抬高急性心肌梗死患者预后关系  

Brain natriuretic peptide and high sensitivity C-reactive prote of different time in assessment of the effect in old patients with NSTEMI

作　　者：孙暴燕 刘永[1] 赵雅琳[1] 富平[1] 

机构地区：[1]沈阳医学院附属中心医院心内科,辽宁沈阳110024

出　　处：《中国急救医学》2016年第9期804-807,共4页Chinese Journal of Critical Care Medicine

基　　金：沈阳医学院临床研究发展基金项目（20137065）

摘　　要：目的探讨血浆脑钠肽（BNP）及超敏C-反应蛋白（hs-CRP）水平与老年非ST段抬高急性心肌梗死（NSTEMI）患者预后关系。方法人选102例老年NSTEMI患者，于入院后测定即刻、14d、30d血浆BNP和hs-CRP水平。所有患者入院后7d、6个月行超声心动图检查，随访住院期间及出院12个月内不良心脏事件。结果左心室重塑组（△LVEDVI≥20％）的入院即刻BNP和hs-CRP的水平[（596．6±136．O）ng／L、（3．36±1．98）mg／L]与无左心室重塑组（ALVEDVI〈20％）比较[（222．3±118．0）ng／L、（1．82±1．23）mg／L]明显升高（P〈0．05），有心血管事件组的入院即刻BNP、hs-CRP水平[（563．9±181．0）ng／L、（3．93±3．01）mg／L]与无心血管事件组[（327．2±179．0）ng／L、（1．66±1．45）mg／L]比较明显升高（P〈0．05）。30dhs-CRP水平在左心室重塑组（ALVEDVI≥20％）与无左心室重塑组（ALVEDVI〈20％）比较，差异无统计学意义[（1．65±1．26）mg／LVS．（1．41±1．12）mg／L，P〉0．05]。结论早期血浆BNP和hs—CRP水平对老年NSTEMI患者预后的预测作用更强。Objective To investigate the relation of the plasma of brain natriuretic peptide （BNP） and high sensitivity C reactive protein （hs-CRP） and prognosis in old patients with non-ST seg- ment elevated myocardial infarction （NSTEMI）. Methods Data of 102 old patients who aged greater than 60 years and occurred NSTEMI were collected. The plasma BNP and hs-CRP were measured imme- diately, 14 days, 30 days after the occurrence of NSTEMI. Echocardiogram was checked at 7 days and 6 months. Results The immediately plasma BNP and hs-CRP levels [ （596.6±136.0）ng/L, （3.36±1.98） mg/L] were significantly higher in left ventricular remodeling group （△LVEDVI ≥ 20% ） than the levels [ （222.3± 118.0） ng/L, （1.82± 1.23） mg/L] of BNP and hs-CRP which is not in left ventrieular remodeling group （△LVEDVI 〈 20% ）; P 〈 0.05 ）. The immediately plasma BNP and hs-CRP levels [ （563.9± 181 ） ng/L, （3.93 ± 3.01 ） mg/L] were also significantly higher in the group with heart events than the levels [ （327.2±179 ng/L, （1.66±1.45） mg/L] of BNP and hs-CRP in the group without heart events （P〈 0.05 ）. 30 days hs-CRP levels had no statistical significance in left ventricular remodeling group.Conclusion The early plasma of BNP and hs-CRP is clinically important for predicting the prognosis of old NSTEMI patients.

关 键 词：脑钠肽(BNP) 超敏C-反应蛋白(hs-CRP) 非ST段抬高急性心肌梗死(NSTEMI) 

分 类 号：R542.22[医药卫生—心血管疾病]