急性心肌梗死患者Th22和Th17细胞水平及其与侧枝循环形成的相关性分析  

Analysis of the correlation between the level of Th22, Th17 and collateral circulation formation in patients with acute myocardial infarction

作　　者：郑永红[1] 项国剑 陈德伟[1] 

机构地区：[1]福建省立医院心内科,福建福州350001

出　　处：《中国急救医学》2016年第9期824-828,共5页Chinese Journal of Critical Care Medicine

摘　　要：目的探讨急性心肌梗死acute myocardial infarction，AMI）患者Th22、Th17细胞水平及其与侧枝循环形成的相关性。方法比较我院2015-01—2016-01收治的98例AMI患者（无侧枝循环组50例＋有侧枝循环组48例）与50例健康人PCI术前及术后2周外周血Th22、Th17细胞水平，并比较无侧枝循环组与有侧枝循环组患者PCI术前及术后2周Gensini评分及血清肌钙蛋白T（troponin T，TnT）水平，分析外周血Th22、Th17细胞水平对侧枝循环形成的影响。结果无侧枝循环组与有侧枝循环组PCI术前及PCI术后2周外周血Th22、Th17细胞水平均明显高于对照组，差异有统计学意义（P〈0．05）；无侧枝循环组PCI术前外周血Th22、Th17细胞水平均明显高于有侧枝循环组，差异有统计学意义（P〈0．05）；无侧枝循环组PCI术后2周外周血Th22、Th17细胞水平与有侧枝循环组比较，差异无统计学意义（P〉0．05）；无侧枝循环组PCI术前Gensini评分及血清TnT水平均明显低于有侧枝循环组，差异有统计学意义（P〈0．05）；两组患者PCI术后2周Gensini评分及血清TnT水平比较，差异无统计学意义（P〉0．05）。结论外周血Th22、Th17细胞水平可作为辅助诊断AMI的依据，其水平高低与AMI病情严重程度及侧枝循环的形成有紧密联系。Objective To explore the correlation between the level ofTh22, Th17 and collateral circulation formation for the patients with acute myocardial infarction. Methods Ninety-eighty patients with acute myocardial infarction were researched as the no-major aortapulmonary collateral arteries group （50 cases） and the aortapulmonary collateral arteries group （48 cases）; 50 cases of healthy indi- viduals were researched as the control group. The levels of Th22, Th17 were compared; the scores of Gen- sini and the levels of TnT were compared for the no-major aortapulmonary collateral arteries group and the aortapulmonary collateral arteries group; the influence on the collateral circulation formation of Th22, Th17 were analyzed. Results The levels of Th22, Th17 before and after PCI for the no-major aortapulmonary collateral arteries group and the aortapulmonary collateral arteries group were higher than those in the control group （P 〈 0.05）. The levels of Th22, Th17 before and after PCI for the no-ma- jor aortapulmonary collateral arteries group were higher than those of the aortapulmonary collateral arter- ies group （P 〈 0.05）. The scores of Gensini and the levels of TnT before PCI for the no-major aortapul- monary collateral arteries group were lower than those in the aortapulmonary collateral arteries group （P 〈 0.05）. There were no significant differences on the scores of Gensini and the levels of TnT after PCI for the no-major aortapulmonary collateral arteries group and the aortapulmonary collateral arteries group （P 〈 0.05）. Conclusion Circulating Th22, Th17 levels can assist the diagnosis of acute myocar- dial infarction, and it also correlates with the severity of illness and collateral circulation formation.

关 键 词：急性心肌梗死(AMI) TH22细胞 TH17细胞 侧枝循环 

分 类 号：R541.4[医药卫生—心血管疾病]