拟缺香茶菜中化学成分研究  

Studies on chemical constituents of Isodon excisoides

作　　者：代丽萍[1,2] 赵猛[1] 李春[3] 赵姣姣[1] 张玲霞[1] 陈随清[1] 高慧敏[3] 王智民[3] 

机构地区：[1]河南中医药大学药学院,河南郑州450046 [2]呼吸疾病诊疗与新药研发河南省协同创新中心,河南郑州450046 [3]中国中医科学院中药研究所,北京100700

出　　处：《中国中药杂志》2016年第18期3361-3365,共5页China Journal of Chinese Materia Medica

基　　金：河南省青年骨干教师项目(2012GGJS-095);河南省中医药管理重点项目(2013ZY02063);省属高校基本科研业务经费(2014 KYYWF-QN02)

摘　　要：采用大孔吸附树脂柱色谱、硅胶柱色谱、Sephadex LH-20凝胶柱色谱以及半制备型高效液相色谱等多种色谱分离技术从拟缺香茶菜干燥的地上部分的水提取液中分离得到6个化合物,综合运用1D-NMR,2D-NMR以及HR-ESI-MS等谱学方法对它们进行了结构鉴定,分别鉴定为3-O-β-D-阿洛糖-1-辛烯-3-醇（1）,布鲁门醇A（2）,光色素（3）,黑麦角内酯（4）,线蓟素（5）和胡麻素（6）。其中化合物1为新化合物,化合物2~4为首次从该植物中分离得到。The chemical constituents of the water extraction of the aerial parts of lsodon excisoides were investigated by various chro- matographic methods including D-101 macroporous adsorptive resins, silica gel, Sephadex LH-20, MCI and semi-preparative HPLC. As a result, six compounds were separated and purified. By analyses of the HR-ESI-MS, ID and 2D NMR spectra, their structures were determined as 3-O-β-D-allopyranosyl-l-octen-3-ol（1）, blumenolA （2）, lumichrome （3）, loliolide（4）, cirsiliol（5） and pedal- itin（6）. Compound 1 was a new compound, and compounds 2-4 were isolated from this plant for the fiist time.

关 键 词：拟缺香茶菜 3-O-β-D-阿洛糖-1-辛烯-3-醇 布鲁门醇A 光色素 

分 类 号：R284[医药卫生—中药学]