七氟醚对产科全身麻醉母体热休克蛋白70的影响  

Effects of Sevoflurane for maternal HSP70 in general anesthesia in caesarean operation

作　　者：李屹[1] 贾杰[2] 孙艺娟[2] 苏丹晨[2] 孙维国[2] 李海洋[2] 

机构地区：[1]广东省妇幼保健院妇科,广州市510010 [2]广东省妇幼保健院麻醉科,广州市510010

出　　处：《实用医学杂志》2016年第17期2915-2917,共3页The Journal of Practical Medicine

基　　金：广东省医学科研基金项目(编号:A2014104)

摘　　要：目的:通过监测剖宫产术中不同时点产妇血浆中热休克蛋白70(HSP70)的浓度及胎儿娩出后胎盘组织中HSP70的表达,评估七氟醚或异丙酚全身麻醉下围术期应激反应的变化,为安全有效地施行产科全身麻醉提供思路与依据。方法 :选择足月产妇60例,拟在全麻下行择期剖宫产手术,采用随机数字表法分为异丙酚组(P组)与七氟醚组(S组),每组30例。记录产妇各时点血中HSP70浓度及胎儿娩出后胎盘组织的HSP70的表达情况。结果:P组术毕时的HSP70浓度水平明显高于术前,差异有统计学意义(P<0.05);与S组同时点比较,差异有统计学意义(P<0.05);胎盘娩出后,P组胎盘组织HSP70表达明显高于S组(P<0.05)。结论:七氟醚用于剖宫产术全身麻醉安全有效,能减少母血HSP70的浓度及胎盘组织HSP70的表达。Objective Using Sevoflurane in general anesthesia in cesarean operation, to evaluate change of stress response by monitoring maternal plasma concentrations of HSP70 and the expression of HSP70 in the placenta tissue and provide an ideal and basis of salty and effectiveness in obstetric general anesthesia. Methods Sixty caesarean operation puerperas undergoing general anesthesia in women and children＇s hospital of Guangdong province were selected and randomly divided into the sevoflurane group （S group） and the propofol group （P group） through random number table, each group had 30 cases. We tested materal blood concentration and expression of HSP70 in placenta tissue. Results HSP70 concentration （when） in the P group was significantly higher than that before surgery （P 〈 0.05） ; Comparing with the group S at the same time point, the difference was statistically significant （P 〈 0.05）; In expression of HSP70 in placental tissue, P group was obviously higher than the S group （P 〈 0.05）, Conclusion Sevoflurane used in general anesthesia for cesarean operation is safe and effective, which can reduce the concentration of HSP70 in maternal blood and expression of HSP70 in placental tissue.

关 键 词：热休克蛋白70 七氟醚 剖宫产 全身麻醉 胎盘组织 

分 类 号：R614.2[医药卫生—麻醉学]