高效液相色谱法测定食品模拟物中的二羟基联苯和二氯二苯砜  

HPLC Determination of Bisphenol and Dichlorophenyl Sulfone in Food Simulant

作　　者：谢文缄 席绍峰 谢永萍 陈意光 李慧勇 

机构地区：[1]广州质量监督检测研究院,国家包装产品质量监督检验中心(广州),广州510110

出　　处：《理化检验（化学分册）》2016年第9期1100-1103,共4页Physical Testing and Chemical Analysis(Part B:Chemical Analysis)

基　　金：广州市质量技术监督局科研项目(2015kj11)

摘　　要：选择了包括95%(φ)乙醇溶液在内的6种不同溶质的溶液作为模拟介质,并分别试验了在与食品包装材料或容器接触过程中,其可能含有的4,4′-二羟基联苯(BPH)和4,4′-二氯二苯砜(DCPS)的迁移量。测定采用Waters Xbridge液相色谱柱,以不同比例配制的甲醇-水混合液作为流动相进行梯度洗脱,用二极管阵列检测器,测定波长为254nm。所得结果表明:方法的测定下限(10S/N)为0.015mg·kg^(-1)。在3个浓度水平上用标准加入法对方法的回收率进行检测,测得回收率在89.0%~106%之间,测定值的相对标准偏差(n=6)均小于4%。另应用此方法测定了聚亚苯基砜(PPSU)奶瓶中上述两化合物在相应模拟介质中的迁移量,结果两者均未被检出。Six solutions containing various solutes, including 95% （φ） ethanol solution were selected as simulated media, and 4, 4＇-dihydroxy-biphenyl （BpH） and 4, 4＇-dichloro-diphenyl sulfone （DCPS）, which were possibly migrated from the food-packaging materials or containers during their contaction with these media, were determined separately by HPLC. Waters Xbridge-liquid chromatographic column was used as stationary phase, while mixtures of methanol and water in various ratios were used as mobile phase in gradient elution. UV-detection with DAD at the wavelength of 254 rim was adopted. As shown by the testing results, value of lower limit of determination （10S/N） found for the method was 0. 015 mg· kg^- 1. Recovery was tested by standard addition method at 3 concentration levels, giving values of recovery in the range of 89. 0%-106%, and values of RSD＇s （n=6） found were all less than 4%. Amounts of migration of the 2 above mentioned compounds in various simulated media in contact with a PPSU feeding bottle as the food container were tested by the proposed method, but none of the 2 compounds was detected.

关 键 词：高效液相色谱法 食品包装材料 食品包装容器 模拟介质 4 4’-二羟基联苯 4 4’-二氯二苯砜 

分 类 号：O652.63[理学—分析化学]