纳米二氧化铈体外生物学效应及作用机制的研究进展  

Progress on Biological Effects in Vitro and Relevant Mechanisms of Nanoceria

作　　者：吴涛[1] 吕丽萍[1] 杨静[1] 杨通旺 张博闻[1] 张志强[1] 吴刚[1] 

机构地区：[1]内蒙古科技大学包头医学院基础医学与法医学院,内蒙古包头014060

出　　处：《环境与职业医学》2016年第9期906-910,共5页Journal of Environmental and Occupational Medicine

基　　金：国家自然科学基金(编号:81160341)

摘　　要：纳米二氧化铈是最重要的纳米稀土氧化物,被广泛应用于各个领域,随着其用途的不断增加,人们在生活环境中与纳米二氧化铈的接触机会增大,其生物安全性逐渐引起了人们的关注,对环境和人类健康影响的争议也愈来愈多。目前对于纳米二氧化铈生物效应的研究争议很大,既有正面效应也有负面效应的报道。本文重点综述纳米二氧化铈对细胞的毒性及可能的作用机制,系统归纳了纳米二氧化铈与活性氧产生的相互作用以及其对DNA损伤、自噬、丝裂原活化蛋白激酶信号通路的作用,为纳米二氧化铈的安全评价提供科学依据。Nanoceria, as the most important nano-sized rare earth oxide, is widely used in various fields. With the increase of its use, people are more likely to be exposed to nanoceria, and the concerns about its biological safety gradually attract more attention with increasing controversies over its impacts on environmental and human health. At present, both positive and negative effects are reported when it comes to biological effects of nanoceria. This review overviewed the interaction between nanoceria and reactive oxygen species as well as related effects on DNA damage, autophagy, and mitogen-activated protein kinase （MAPK） pathway. This review focused on cytotoxicity and possible mechanism of nanoceria in order to provide a scientific basis for human health safety assessment.

关 键 词：纳米二氧化铈 氧化损伤 抗氧化 DNA 自噬 丝裂原活化蛋白激酶信号通路 

分 类 号：R12[医药卫生—环境卫生学]