骨修复材料HAPw/n-ZnO抗感染效果的实验研究  

Experimental study on anti-infection effect of bone repair material HAPw/n-ZnO

作　　者：代宏伟[1] 张文云[2] 陈庆华[3] 袁艳波[2] 杨立斗[2] 

机构地区：[1]昆明医科大学,云南昆明650500 [2]成都军区昆明总医院.昆明医科大学教学医院口腔科,云南昆明650032 [3]昆明理工大学材料科学与工程学院,云南昆明650093

出　　处：《临床口腔医学杂志》2016年第8期451-455,共5页Journal of Clinical Stomatology

基　　金：国家自然科学基金项目(619220120058)

摘　　要：目的:通过动物实验观察HAPw/n-ZnO在感染性骨缺损中的抗感染效果。方法:在24只SD大鼠(雌雄不限,220 g-250 g)左后肢股骨外侧髁处制备环状骨缺损,在缺损区置入金葡菌溶液(1×104CFU/m L,ATCC6538),2周后随机分为两个实验组(n=14)和一个空白组(n=7),对实验组骨缺损区行清创术后植入骨修复材料,空白组仅行清创术。于术后2周处死动物,进行组织切片及细菌学检查。结果:实验组对比空白对照组具有一定的抑菌抗感染的效果,其中HAPw/n-ZnO效果最为明显。结论:HAPw/n-ZnO能抑制金葡菌的生长,控制感染。Objective：Anti-infection effect of HAPw/ZnO composite material on infected bone defect through animal test was observed.Method：Circular bone defect was made on the left rear lateral condyle of femur of 24 SD rats（220-250 g of either sex）,where the S.aureus solutions were sent（1 ×104 CFU/ml）.After two weeks,the rats were divided into experiment group （ n =14 ） and a blank group （ n =7 ） randomly.Both of the groups did debridement on the bone defect area,however,only the experiment group were further implanted the bone repairing material.The rats were executed within 2 weeks after surgery and then,tissue slice and bacterio-logical examination were carried out.Results：In contrast with the blank comparison group,the experiment group showed certain bacteriostatic and anti-infection effect,especially for HAPw/ZnO.Conclusion：HAPw/ZnO com-posite material can inhibit the growth of S.aureus and control the infection of bone defect.

关 键 词：人工骨修复材料 HAPw/n-ZnO 感染性骨缺损 抗感染 

分 类 号：R318.08[医药卫生—生物医学工程]