CGF联合骨代用品及口腔修复膜在颌骨囊肿手术中的应用  

Application of CGF combined with biodegradable coral-hydroxyapatite ceramic and oral biofilm in reconstruction of bone defects after removal of jaw cysts

作　　者：李伯友[1] 苏铭扬[1] 李阳[1] 林璇[1] 吴熙凤[2] 高永波[1] 

机构地区：[1]深圳市龙岗中心医院口腔科,广东深圳518116 [2]深圳市龙岗区人民医院口腔科,广东深圳518172

出　　处：《临床口腔医学杂志》2016年第8期476-478,共3页Journal of Clinical Stomatology

基　　金：广东省自然科学基金资助面上项目(S2013010014978);广东省深圳市科技计划项目(JCYJ20140414124506131);广东省深圳市科技计划项目(CXZZ20130517140636687);广东省深圳市龙岗区科技发展项目(YS2013006)

摘　　要：目的：观察浓缩生长因子（ CGF）联合羟基磷灰石生物陶瓷及口腔修复膜在颌骨囊肿手术中促进骨组织愈合的临床效果。方法：45例颌骨囊肿患者行囊肿刮除术，采用浓缩生长因子及羟基磷灰石生物陶瓷混合物填充骨腔，CGF膜及口腔修复膜双层覆盖在骨缺损区表面。术后随访3～12个月，通过临床和影像学检查评估治疗效果。结果：45例患者术后伤口均为Ⅰ期愈合。直径＜2 cm的骨缺损在术后3个月羟基磷灰石生物陶瓷与周围骨组织界限消失，可见正常网纹结构的骨小梁。直径＞2 cm的骨缺损，术后9个月羟基磷灰石生物陶瓷与周围骨组织界限模糊；术后12个月界限消失，充填材料与新生骨及周围骨组织生长良好。结论：CGF联合羟基磷灰石生物陶瓷充填颌骨囊肿骨缺损区同时覆盖口腔修复膜的引导骨再生技术可有效促进骨愈合，修复骨缺损。Objective：To investigate the clinical effect of CGF combined with biodegradable coral-hydroxyapatite ceramic and oral biofilm on guiding bone regeneration after removal of jaw cysts.Methods：Forty-five cases of jaw cysts were treated by curettage.The diameter of bone defect ranged from 1.0-4.0 cm.Bone de-fects were filled with CGF and biodegradable coral-hydroxyapatite ceramic.CGF and oral repairing film The area of bone defect were covered by CGF and oral repairing film.All cases were followed-up for 3-12 months.According to the clinical observation and radiological examination,the effect of the treatment was evalua-ted.Results：Forty-five patients were healed by first intention after operation.Three months followed-up after op-eration,the line between biodegradable coral-hydroxyapatite ceramic and surrounding bone disappeared,and bone reticulate structure were observed in jaw cysts with diameter less than 2 cm.The line between coral-hydroxyapa-tite ceramic and surrounding bone were blurry with nine months followed-up.Biodegradable coral-hydroxyapatite ceramic,the new bone tissue and the surrounding bone grown well in jaw cysts with diameter greater than 2 cm in 1 years followed-up.Conclusion：CGF combined with biodegradable coralline hydroxyapatite and oral repairing film could have good effect on reconstruction of bone defects.

关 键 词：浓缩生长因子 羟基磷灰石生物陶瓷 口腔修复膜 颌骨囊肿 骨缺损 

分 类 号：R318.08[医药卫生—生物医学工程]