7-脱氢胆固醇的合成工艺改进  

Process Improvement on the Synthesis of 7-Dehydrocholesterol

作　　者：阿尔吐克.艾沙 

机构地区：[1]新疆油田公司实验检测研究院开发实验中心,新疆克拉玛依834000

出　　处：《合成化学》2016年第9期828-831,共4页Chinese Journal of Synthetic Chemistry

摘　　要：以胆固醇为原料,经酰化、氧化、还原、水解以及消除等5步反应合成维生素D3原7-脱氢胆固醇,总收率42%,其结构经1H NMR和13C NMR确证。研究了酰化反应、氧化反应、还原反应和消除反应条件对收率的影响。7-Dehydrocholesterol,the provitamin D3,was prepared by acetylation,oxidation,reduction,hydrolysis and elimination reactions from cholesterol with 42% total yield. The structure was confirmed by1 H NMR and13 C NMR. The effects of acetylation reaction,oxidation reaction,reduction reaction and elimination reaction conditions on the yield were studied.

关 键 词：胆固醇 烯丙位氧化 7-脱氢胆固醇 合成 

分 类 号：O624.12[理学—有机化学]