雌激素诱导表观遗传模式改变促进巨噬细胞增殖的效应  

Effects of estrogen induced epigenetic changes on the proliferation of macrophages

作　　者：李登坤 木魁 宋浩洋 李金梅[1,2] 吴风瑞[1,2] 李文雍[1,2] 姜双林[1,2] 

机构地区：[1]阜阳师范学院生物与食品工程学院,安徽阜阳236037 [2]胚胎发育与生殖调节安徽省重点实验室,安徽阜阳236037

出　　处：《阜阳师范学院学报（自然科学版）》2016年第3期37-40,共4页Journal of Fuyang Normal University(Natural Science)

基　　金：安徽省教育厅自然科学重点项目(KJ2016A873);青年科学基金项目(3150120144)资助

摘　　要：巨噬细胞的吞噬作用与性别差异有着紧密联系,雌激素能促进巨噬细胞产生干扰素,但其在染色质水平的变化鲜有报道。为了探讨雌激素促进巨噬细胞增殖和生产干扰素的过程中,在染色质水平上的改变,以200 ng/m L的雌激素处理J774A.1巨噬细胞,48小时后检测细胞增殖和表观遗传相关酶基因表达水平的变化。结果表明雌激素能够促进巨噬细胞的增殖和显著改变表观遗传相关酶基因的表达,提出雌激素改变表观遗传模式可能是促进细胞增殖的作用机制之一。The phagorytosis role of macrophages is closely related to gender differences. Estrogen can promote the production of interferon by macrophages, but the changes in chromatin levels are rarely reported. For the study a change in the chromatin level,in while estrogen promote the process of macrophage proliferation and production of interferon. Treat J774 A.1 macrophages with 200 ng/m L estrogen, after 48 h of cell proliferation and associated epigenetic detection gene expression levels. The results show that estrogen can promote the proliferation of macrophages and significantly alter the expression of epigenetic-related gene. Thus, one of the mechanisms of promoting cell proliferation is to suggest that the epigenetic pattern of estrogen changes.

关 键 词：巨噬细胞 雌激素 表观遗传 细胞增殖 

分 类 号：Q28[生物学—细胞生物学] R392.12[医药卫生—免疫学]