曲司氯铵治疗壁内段输尿管结石所致膀胱激惹症状的疗效研究  

Efficacy of Trospium Chloride for Medical Treatment of Intramural Ureteral Stone with Vesical Irritability

作　　者：吕建林[1] 唐庆来[1] 

机构地区：[1]南京医科大学附属江宁医院泌尿外科,江苏南京211100

出　　处：《中国医药指南》2016年第24期15-16,共2页Guide of China Medicine

摘　　要：目的探讨曲司氯铵在治疗壁内段输尿管结石所致的膀胱激惹症状的疗效。方法本研究选取2013年12月至2014年12月间共65例壁内段输尿管结石患者作为研究对象,并将其分为两组,A组31例给予观察等待作为对照组;B组34例给予曲司氯铵20 mg,每日2次,作为治疗组,共观察两周。观察指标为清石率、排石时间,疼痛程度等数据。应用排尿感觉量表(USS)描述患者膀胱激惹的程度及视觉模拟量表(Visual Analog Scale,VAS)疼痛评分来记录患者的疼痛程度。结果 A组和B组的清石率分别为54.8%,70.6%(P=0.032)。A组和B组发生肾绞痛的平均次数分别为4.1、1.5。观察的第3、7天,两组的平均USS评分分别为(2.51±0.68)、(1.27±0.51);(2.10±0.74)、(1.15±0.43)(P<0.05)。两组VAS评分分别在第3天和第7天进行比较,均具有显著的统计学差异。结论曲司氯铵对促进壁内段输尿管结石的排出有一定的作用,且它能减少此类患者的尿频、尿急症状,减轻疼痛的强度和不适感。Objective To study the afficacy of trospium chloride for medical treatment of intramural ureteral stone with vesical irritability. Methods A total of 65 patients with intramural ureter stones were include in the study from December 2013 to December 2014. Patients were randomly divided into two groups. The 31 patients in group A were given a watchful waiting and served as control group. The 34 patients in group B received 20 mg trospium chloride （twice a day）. Both groups were followed up 2 weeks. The stone expulsion rate and time and the number of pain episodes were obtained. Subjects rated the urgency associated with each micturition using the Urinary Sensation Scale（USS）. Pain descriptions were recorded by the patients using the Visual Analogy Scale （VAS）. Results The stone expulsion rate in groups A and B was 54.8% and70.6%（P=0.032）, respectively. The mean numbers of renal colic episodes of patients in groups A and B had experienced 4.1 and 1.5, respectively. The USS for groups A and B in 3 and 7 days were （2.76±0.72）, （1.32±0.47）; （1.90±0.64）, （1.18±0.39）, respectively （P〈0.001）. Statistically significant difference was found between groups A and B in relation to the VAS score on days 3 and 7, respectively（P〈0.001）. Conclusions The study demonstrated that trospium chloride reduced the common symptoms of frequency, urgency, intensity of the pain episodes and discomfort often associated with intramural ureter stone and there were improvement in expulsion stone rate.

关 键 词：曲司氯铵 壁内段输尿管结石 膀胱激惹症 

分 类 号：R693.4[医药卫生—泌尿科学]