沈阳市某学校教师的亚健康情况及外周血淋巴细胞亚群分析  

Sub-healthy condition of teachers in a school of Shenyang City and their peripheral blood lymphocyte subsets analysis

作　　者：严峰[1] 许园园 王萍[3] 吴姗姗[1] 张艺凡[1] 

机构地区：[1]辽宁中医药大学附属医院临床检验中心,沈阳110032 [2]辽河油田第二职工医院检验科,辽宁盘锦124000 [3]辽宁中医药大学附属医院血液科,沈阳110032

出　　处：《检验医学与临床》2016年第18期2561-2563,2566,共4页Laboratory Medicine and Clinic

基　　金：辽宁省省直医院改革重点临床科室诊疗能力建设项目青年项目(LNCCC-D52-2015)

摘　　要：目的统计沈阳市某学校教师的亚健康情况和分析亚健康状态时外周血淋巴细胞亚群的变化。方法采用现场调查的方法,对参加体检的教师发放亚健康调查表,判断教师健康状况。同时,检测健康教师和亚健康教师的淋巴细胞亚群。同期住院肿瘤患者淋巴细胞亚群结果作为对照。结果共有584名教师问卷合格,其中健康人群300例,患病需治疗的9例,亚健康状态人群275例,亚健康发生率为47.09%,健康教师淋巴细胞亚群分析中,总T细胞、辅助性T细胞(Th)、抑制性T细胞(Ts)、自然杀伤细胞(NK)和B细胞比例分别为(67.19±8.95)%、(37.58±7.23)%、(28.14±7.66)%、(21.16±9.97)%、(9.56±3.80)%。亚健康职工上述细胞比例分别为(65.22±7.75)%、(35.90±7.22)%、(28.87±8.02)%、(24.57±8.33)%、(9.61±4.66)%。同年度肿瘤患者上述细胞比例分别为(60.65±14.39)%、(30.32±15.22)%、(26.36±9.51)%、(30.25±13.36)%、(5.37±4.29%)。亚健康组与健康组比较总T细胞、Th、NK细胞比例差异均有统计学意义(P<0.05),Ts及B细胞比例无明显差异。亚健康组与肿瘤组比较总T细胞、Th、Ts、NK细胞及B细胞比例差异均有统计学意义(P<0.05),健康组与肿瘤组比较总T细胞、Th、Ts、NK细胞及B细胞比例差异均有统计学意义(P<0.05)。结论教师亚健康状态的临床表现多样,其健康状况不容乐观。Objective To perform the statistics on the sub‐healthy conditions of teachers in a school of Shenyang City and to an‐alyze the peripheral blood lymphocyte subsets changes .Methods The field investigation method was adopted and the the sub‐health tables were issued for judging the teachers′ health condition .Meanwhile the lymphocytes subsets were detected in the healthy teach‐ers and sub‐healthy teachers .The lymphocytes subsets results in contemporaneous tumor inpatients were taken as control .Results The questionnaires were qualified in 584 teachers .Among them ,300 cases were the healthy crowd ,9 cases needed to treat and 275 cases were in the sub‐healthy status ,the sub‐healthy occurrence rate number of qualified table is ,of which 300 healthy people ,sick people in need of treatment 9 ,275 sub‐health state ,and the rate of sub‐health number of healthy people is 47 .09 % .In the lympho‐cyte subsets of healthy people ,The percent of T was 47 .09% .In the lymphocytes subsets analysis of healthy teachers ,the total T cells ,helper T cells（Th） ,suppressor T cells（Ts） ,natural killer cells（NK） and B cells were （67 .19 ± 8 .95）% ,（37 .58 ± 7 .23）% , （28 .14 ± 7 .66）% ,（21 .16 ± 9 .97）% and（9 .56 ± 3 .80）% respectively ,which in the sub‐healthy staff were （65 .22 ± 7 .75）% , （35 .90 ± 7 .22）% ,（28 .87 ± 8 .02）% ,（24 .57 ± 8 .33）% and （9 .61 ± 4 .66）% respectively .The proportions of above cells in the tumor patients in the same year were （60 .65 ± 14 .39）% ,（30 .32 ± 15 .22）% ,（26 .36 ± 9 .51）% ,（30 .25 ± 13 .36）% and （5 .37 ± 4 .29）% respectively .Conclusion The clinical manifestations of the sub‐healthy status in teachers are various .Their healthy condi‐tion is not optimistic .The total T cells ,Th cells and NK cells had statistically significant differences between the sub‐healthy group and healthy group（P〈 0 .05） ,however Ts and B cells had no obvious difference between the two groups ,the t

关 键 词：亚健康状态 淋巴细胞亚群 辅助性T细胞 抑制性T细胞 NK细胞 B细胞 

分 类 号：R392.12[医药卫生—免疫学]