肝素结合表皮生长因子的高表达与稽留流产病因的相关性研究  

Research on the correlation of up-regulated heparin-binding epidermal growth factor(HB-EGF) and missed abortion

作　　者：罗树玲 郑春艳 曹锦慧 

机构地区：[1]榆林市星元医院妇产科,陕西榆林719000

出　　处：《中国性科学》2016年第9期101-104,共4页Chinese Journal of Human Sexuality

摘　　要：目的:肝素结合表皮生长因子(HB-EGF)在女性生殖系统中有非常重要的作用,它能促进子宫内膜从增殖期向分泌期转化,并且介导受精卵着床,促进胎盘的形成和生长,同时也有抑制凋亡的作用。本研究意在探讨HB-EGF在稽留流产的病因中所起到的作用。方法:选取意外妊娠的患者12例作为对照组,稽留流产的患者13例为实验组,采用人流术或刮宫术取得子宫蜕膜组织和胎盘组织,利用免疫组织化学染色的方法检测实验组和对照组的蜕膜组织与胎盘组织里的HB-EGF的水平。结果:稽留流产患者的蜕膜组织与胎盘组织内的HB-EGF表达均有上调[分别是(143.31±12.50)和(115.72±12.13)],并且明显高于对照组的蜕膜组织与胎盘组织内的HB-EGF表达[分别是(102.40±13.21)和(82.30±9.97)]。结论:研究数据表明HB-EGF的高表达在稽留流产中可能是导致死胎滞留腹中的原因。Objectives： Heparin - binding epidermal growth factor（ HB - EGF） has important biologic functions in the female reproductive tract. It helps to promote the uterine from proliferation stage to secretory stage, and has functions in implantation, placenta development, and also inhibition of apoptosis. This research aims to explore the possible role of HB EGF in missed abortion. Methods ： Deeidual and placental tissue samples were obtained from 12 women with unwanted pregnancy as the control group and from 15 women with missed abortions as the experiment group, hnnmnohistochemistry was used to compare HB - EGF expression in uterine decidual tissue and in placental villous stroma of the two groups. Results： HB - EGF expression in both uterine decidual tissue and placental villous stroma was up - regulated in the missed abortion group （ 143.31± 12.50 and 115.72 ± 12.13 respec- tively）, compared with the control group （ 102.40 ±13.21 and 82.30 ±9. 97102.4, respectively）. Conclusion： The up - regulated expression of HB - EGF may inhibit the discharge of dead fetus in missed abortions.

关 键 词：肝素结合表皮生长因子 稽留流产 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]