小儿肺咳糖浆质量标准研究  

Quality Standards Research of Pediatric Cough Syrup

作　　者：唐立海[1] 冼小敏[1] 李炯祥 朱寿光 

机构地区：[1]东莞市食品药品检验所,广东东莞523109

出　　处：《亚太传统医药》2016年第18期27-30,共4页Asia-Pacific Traditional Medicine

摘　　要：目的：采用化学反应、薄层色谱法（TLC）和高效液相色谱法分别进行小儿肺咳糖浆的定性、定量检测，研究小儿肺咳糖浆质量标准。方法：采用化学反应对铵盐和氯化物进行定性鉴别，采用TLC对处方中甘草进行定性鉴别；采用高效液相色谱法测定糖浆中甘草酸铵的含量。结果：鉴别方法专属性强，甘草酸铵在0．0936～1．8713μg·mL-1范围内浓度与峰面积线性关系良好，r=1（n=6），平均回收率为103．72％，RSD=1．5。结论：该方法简便，灵敏度高，重复性好，可有效控制止咳糖浆的质量。Objective：The qualitative identification of cough syrup and quality standard were studied. Methods：The chemical reactions for qualitative identification and ammonium chloride; By thin layer chromatography （TLC method） of liquorice in the prescription qualitative identification; Using high performance liquid chromatography （HPLC） method for determining the content of ammonium glycyrrhetate in syrup. Results：The chemical reaction and TLC identification method of specific, ammonium glycyrrhetate in 0. 0936-1. 8713μg·mL-1 good linear relationship between concentration and peak area in range,r=1 （n= 6）, the average recovery was 103.72% ,RSD= 1.5. Conclusion： This method is simple,high sensitivity,good repeatability,can be used for quality control of lung cough syrup.

关 键 词：小儿肺咳糖浆 甘草酸铵 薄层色谱法 高效液相色谱 

分 类 号：R286.0[医药卫生—中药学]