固相萃取-高效液相色谱串联质谱测定水中PPCPs残留  

Determination of Pharmaceuticals and Personal Care Products in Water by Solid-phase Extraction and High-performance Liquid Chromatography-Tandem Mass Spectrometry

作　　者：刘世泽[1] 肖敏如[2] 吴卿[1] 张新波[3] 赵新华[1] 

机构地区：[1]天津大学环境科学与工程学院,天津300072 [2]天津市城市规划设计研究院,天津300201 [3]天津城建大学环境与市政工程学院,天津300384

出　　处：《中国给水排水》2016年第18期113-117,共5页China Water & Wastewater

基　　金：国家自然科学基金资助项目(51378338)

摘　　要：基于固相萃取(SPE)-高效液相色谱串联质谱(HPLC/MS/MS)技术,建立了水中18种PPCPs化合物同时定量检测的方法。并对前处理中影响目标化合物回收率各因素(水样p H值、洗脱液、复溶液)以及仪器检测参数进行优化。研究发现,18种PPCPs化合物按照最优p H值可以分为三组,最优pH值分别为2、4.5、9;洗脱液采用10 m L纯甲醇可以充分地洗脱目标化合物;复溶液采用乙腈-甲酸水混合液(体积比为1∶9)可以出现较好的峰形;检测采用正离子模式,流动相流速采用0.3 m L/min,检测时间为36 min,可以较为准确地对化合物定量。将该方法应用于天津给水系统饮用水中PPCPs的检测,结果令人满意。The synchronous rapid analysis method of 18 types of PPCPs was set up based on solid phase extraction and HPLC/MS/MS. The factors affecting the efficiency of pretreatment （ pH, eluent and redissolved solvent） and detection precision were optimized. The results showed that the samples were adjusted to three distinct pH values （2, 4.5 and 9） to achieve satisfactory recoveries for different compounds. The target compounds could be effectively eluted with methanol of 10 mL. Excellent peak shape could appear when the mixture of acetonitrile and ultrapure water with formic acid （volume ratio of 1 ： 9） was used as redissolved solvent. The target compounds could be accurately quantified with positive ion mode when the flow rate was 0.3 mL/min and the determination time was 36 min. The method was suc- cessfully applied to the detection of PPCPs compounds in drinking water system in Tianjin.

关 键 词：制药和个人护理产品(PPCPs) SPE HPLC-MS-MS 

分 类 号：X832[环境科学与工程—环境工程]