国内益生菌制剂预防新生儿坏死性小肠结肠炎的Meta分析  

Preventive effect of probiotic preparations on neonatal necrotizing enterocolitis:A Meta analysis

作　　者：舒红文[1] 柴建华[1] 周川芬[1] 常洪美[1] 韩燕[1] 

机构地区：[1]崇州市人民医院,四川崇州611230

出　　处：《中国微生态学杂志》2016年第9期1040-1043,共4页Chinese Journal of Microecology

摘　　要：目的系统评价益生菌制剂在预防新生儿坏死性小肠结肠炎(NEC)的临床效果。方法计算机联机检索数据库,应用RevMan 5.3软件,对益生菌制剂治疗预防NEC的随机对照试验(RCT)所收集的数据资料进行Meta分析。结果纳入9篇RCT文献中包涵2 058例新生儿,对预防NEC的发生率进行Meta分析。结果显示益生菌制剂预防NEC的效果优于对照组[OR=0.20,95%CI(0.12,0.33),P<0.000 01]。结论给予益生菌制剂治疗,可降低NEC的发生率。Objective To evaluate the clinical effect of probiotic preparations in the prevention of neonatal necrotizing enterocolitis（NEC）.Methods RevMan 5.3software was used to perform a Meta analysis on the data of randomized controlled trials（RCTs）on probiotic preparations for treatment and prevention of NEC retrieved from relevant database.Results 9RCT literatures were retrieved,which included 2,058 newborns.Meta analysis result showed that probiotic preparations were superior to the control groups in the prevention of NEC（OR=0.20,95%CI [0.12,0.12],P〈0.000 01）.Conclusion Pay treatment,probiotic preparations can reduce the incidence of NEC.

关 键 词：益生菌制剂 新生儿 坏死性小肠结肠炎 META分析 

分 类 号：R725.7[医药卫生—儿科]