硬膜外填充制备急性脑死亡模型的初步研究  

A New Kind of Brain Death Model of Pig for Lung Transplantation

作　　者：董彦军[1] 郑先杰[1] 张国瑜[1] 廖秋明 杨忠信[1] 孙明飞[1] 安小康[1] 潘丽红[1] 张双林[1] 

机构地区：[1]河南大学第一附属医院胸心血管外科,河南开封475001 [2]瑞典lund大学医院胸心外科

出　　处：《中国继续医学教育》2016年第25期72-73,共2页China Continuing Medical Education

摘　　要：目的应用硬膜外骨蜡填充,制造颅内占位,建立急性脑死亡模型。方法瑞典家猪30头随机分为脑死亡组(B组)和对照组(A组)。B组行开颅术,颅内放置40 ml骨蜡建立脑死亡模型,维持24h;A仅行开颅;检测两组生命体征变化。结果脑死亡组15头全部成功建立模型。B组心率(heart rate,HR)、平均动脉压(mean aortic pressure,MAP),颈动脉血流量(carotid arotic flow,CAF)、血氧饱和度(arterial oxygen saturation,SaO_2)均呈特征性改变,有统计学差异。A组HR、MAP、CAF无明显变化。结论成功建立一个急性猪脑死亡模型,脑死亡后生命体征呈特征性改变。Objective Buliding an acute brain death model by put bone wax into skull, measuring and analyise the chang of hemodynamics.Methods Thirty pigs were divided into two groups randomly： brain death model group （group B）, control group （group A）, for group B： dig a hole on pigs skull and put bone wax into the extradural space, for group A： digging a hole on pigs skull. Values of HR, SaO2, CVP, CAF would be recorded. Results All animals in group B showed a similar pattern in blood pressure registration during the induction of brain death. At the end of the induction, the registration showed a sharp peak. After the peak in MAP had occurred, a decline in heart rate to its basal level. The heart rate and MAP are stable. The CAF of group B showed a sharp peak as MAP. After a period of one hour ,CAF can not be observed. The CAF of group A is stable.Conclusion Acute brain death model is successful induced.

关 键 词：脑死亡模型 病理生理 猪 

分 类 号：R651.11[医药卫生—外科学]