合并糖尿病对急性心肌梗死患者血B型脑钠肽、超敏C反应蛋白和心室重构的影响  

Effects of Diabetes on Serum Brain Natriuretic Peptide, High Sensitive C Reactive Protein and Ventricular Remodeling in Patients with Acute Myocardial Infarction

作　　者：胡敏[1] 葛恒松[1] 李勇[1] 费金雷 

机构地区：[1]江苏省沭阳县人民医院心内科,江苏沭阳223600

出　　处：《中国继续医学教育》2016年第24期89-90,共2页China Continuing Medical Education

摘　　要：目的 合并糖尿病对急性心肌梗死患者血B型脑钠肽、超敏C反应蛋白和心室重构的影响。方法 选取我院2013年7月~2016年2月90例急性心肌梗死患者为研究对象,依据患者是否合并糖尿病分为A、B组,每组45例。A组为合并糖尿病的急性心肌梗死患者,B组为未合并糖尿病的急性心肌梗死患者,患者入院后均给予常规治疗。比较两组治疗前血糖、BNP和hs-CRP水平,并记录治疗前、后左室收缩末径（LVESD）、舒张末径（LVEDD）和左室射血分数（LVEF）。结果 A组血糖（9.58±1.54）mmol/L、BNP（1743.42±526.31）ng/L及hs-CRP（55.97±19.65）ng/L均高于B组,有统计学意义（P〈0.05）。两组治疗前LVESD、LVEDD、LVEF比较无统计学意义（P〉0.05）;B组治疗后LVESD、LVEDD、LVEF均高于治疗前,且高于A组,有统计学意义（P〈0.05）。结论 合并糖尿病可使急性心肌梗死患者BNP、hs-CRP升高,对心室重构有影响,具有一定的临床指导意义。Objective To study the effect of diabetes on serum brain natriuretic peptide, high sensitive C reactive protein and ventricular remodeling in patients with acute myocardial infarction.Methods 90 patients with acute myocardial infarction in our hospital from July 2013 to February 2016 were selected as the research objects, they were divided into group A and group B according to whether patients were complicated with diabetes or not, 45 cases in each group. Acute myocardial infarction patients in group A were complicated with diabetes, acute myocardial infarction patients in group B were not complicated with diabetes, the patients were given routine treatment after admission. Blood sugar, BNP, hs-CRP level were compared between the two groups before the treatment, left ventricular end-systolic diameter （LVESD）, left ventricular end diastolic diameter （LVEDD） and left ventricular ejection fraction （LVEF） before and after the treatment were recorded.Results Blood sugar （9.58±1.54） mmol/L, BNP （1743.42±526.31）ng/L and hs-CRP （55.97±19.65） ng/L in group A were signiifcantly higher than group B （P〈0.05）. There was no signiifcant difference in LVESD, LVEDD, LVEF in the two groups before the treatment （P〉0.05）; LVESD, LVEDD, LVEF in group B after the treatment were signiifcantly higher than those before the treatment, and signiifcantly higher than group A （P〈0.05）.Conclusion Diabetes can increase BNP and hs-CRP of patients with acute myocardial infarction, affect ventricular remodeling, has a lot of clinic signiifcance.

关 键 词：糖尿病 急性心肌梗死 BNP HS-CRP 心室重构 

分 类 号：R542.22[医药卫生—心血管疾病]