I2负载蒙脱土研磨法催化Knoevenagel反应  

I_2 Loaded Montmorillonite as an Efficient Catalyst for Knoevenagel Condensation Under Grinding Method

作　　者：吴小云[1] 尹晓刚[1] 王野[1] 陈治明[1] 陈卓[1] 

机构地区：[1]贵州师范大学化学与材料科学学院,贵州省功能材料化学重点实验室,贵州贵阳550001

出　　处：《福建师范大学学报（自然科学版）》2016年第5期44-50,共7页Journal of Fujian Normal University：Natural Science Edition

基　　金：国家自然科学基金资助项目(21362006)

摘　　要：室温研磨、无溶剂的绿色条件下,以I2负载蒙脱土催化Knoevenagel反应,筛选最优催化剂、碱添加剂、研磨时间及原料物质的量比.实验结果表明:以醋酸钠为碱添加剂,常温研磨10 min后,产率最高可达95.3%.红外、核磁、熔点表征产物,I2负载蒙脱土底物适应性良好并可以循环使用3次,使用此体系合成了具有潜在生物活性的靛红丙二腈衍生物,产率达90.8%.Knoevenagel reaction catalyzed by I2 loaded montmorillonite was developed under grinding and solvent-free conditions at room temperature. Catalyst,base additives,grinding time and the molar ratio of the raw material were screened. The results showed that： when base additive is nitrium acetate,grinding at room temperature for 10 min,the yield up to 95. 3%. The products were characterized by ^1 H NMR,IR and M. P. I2 loaded montmorillonite has a synergistic catalytic effect which can be recycled three times. Isatylidene malononitrile derivatives were prepared in 90. 8%yield which have potential biological activities.

关 键 词：蒙脱土 I2 研磨法 KNOEVENAGEL反应 

分 类 号：O621.3[理学—有机化学]