单核细胞趋化蛋白3研究进展  

Research developments of Monocyte Chemotactic Protein-3

作　　者：孔令爽[1] 柴克霞[1] 

机构地区：[1]青海大学附属医院风湿免疫科,青海西宁810000

出　　处：《医药前沿》2016年第26期11-13,共3页Journal of Frontiers of Medicine

摘　　要：单核细胞趋化蛋白3（MonocyteChemotacticProtein3，MCP-3）属于趋化因子家族中cc亚家族成员之一。近年来研究证实，MCP-3是重要的炎性趋化因子，机体在炎症等因素刺激下，单核细胞、巨噬细胞、内皮细胞、成纤维细胞、肿瘤细胞、气道平滑肌细胞等均可被诱导分泌MCP-3。其在机体防御、组织修复、血管生成、抗肿瘤等过程中发挥着重要作用。本文简要的综述MCP-3及其相关疾病的研究进展。Monocyte Chemotactic Protein 3 （MCP-3） belongs to the family of one factor CC chemokine subfamily members.Recent research indicates that MCP-3 is an important inflammatory chemokine.Under inflammation and other factors to stimulate in the body, monocytes, macrophages, endothelial cells, fibroblasts, tumor cells, airway smooth muscle cells can be induced to secrete MCP-3.It plays an important role in the occurrence and development of host defense,tissue repair, vascular proliferation,anti-tumor.Here is to make a review on the molecular biology and its clinical disease of MCP-3 and its receptor.

关 键 词：单核细胞趋化蛋白3 受体 炎性反应 疾病 

分 类 号：R39[医药卫生—基础医学]