新生儿急性呼吸窘迫综合征多因素分析  

Multiple-factor analyses of neonatal acute respiratory distress syndrome of newborn

作　　者：赵婷[1] 王乐[1] 李明霞[1] 

机构地区：[1]新疆医科大学第一附属医院新生儿病区,乌鲁木齐830054

出　　处：《新疆医科大学学报》2016年第10期1236-1238,共3页Journal of Xinjiang Medical University

基　　金：国家自然科学基金(309604107)

摘　　要：目的探讨新生儿急性呼吸窘迫综合征(ARDS)的症状、体征、发病的危险因素以及与疾病严重程度的关系。方法回顾性分析2011年1月-2015年1月新疆医科大学第一附属医院新生儿病区收治的ARDS患儿172例(重度组61例,轻度组111例),采用卡方检验及成组资料Logistic回归分析探讨新生儿ARDS的相关危险因素。结果 ARDS患儿临床特点:(1)发病时间窗窄;(2)临床症状重。重度组患儿动脉导管未闭、肺动脉高压并发症发生率较轻度组增加,治愈率低,病死率增加。单因素分析示胎龄、无宫缩的剖宫产、出生体重、男性,羊水胎粪吸入、糖尿病母亲新生儿等为新生儿ARDS危险因素;多元Logistic回归分析示:出生体质量、糖尿病母亲新生儿、羊水胎粪吸入、男性为病情严重程度的危险因素。结论新生儿ARDS起病急,病程进展快,并发症发生率高;出生体质量、糖尿病母亲新生儿、羊水胎粪吸入、男性为ARDS的危险因素。Objective To explore newborn acute respiratory distress syndrome（ ARDS） signs,symptoms,the relationship between risk factors and the severity of the disease. Methods 172 cases（ 61 cases of severe group,111 cases of mild group） with acute respiratory distress syndrome were enrolled in this retrospective studies,which were hospitalized in the Department of Neonatolgy in The First Affiliated Hospital of Xinjiang Medical University from January 2011 to January 2015. Chi-square test and Logistic regression analysis were used to explore the related risk factors for ARDS in newborn. Results Clinical features of neonatal ARDS：（ 1） Time window of onset was short;（2） Clinical symptoms is significant. Patent ductus arteriosus,and pulmonary hypertension were higher in the severe group,while the cure rate was decreased,and mortality rate was increased. Impact factors： Gestational age,no contractions of cesarean delivery,birth weight,men,amniotic fluid meconium inhaled,newborns of diabetes mothers,and other risk factors were risk factors for neonatal ARDS with single factor analysis; Multivariate Logistic regression analysis showed that birth weight,newborns of diabetes mothers,amniotic fluid meconium inhaled,men were related to the severity of the disease. Conclusion Neonatal ARDS is characteristic of onset nasty,fast progression,higher incidence of complications. Birth weight,newborns of diabetes mothers,amniotic fluid meconium inhaled,men are the risk factors for ARDS.

关 键 词：新生儿 急性呼吸窘迫综合征 危险因素 

分 类 号：R722[医药卫生—儿科]