肝病患者血清免疫球蛋白及T淋巴细胞亚群检测及其意义  

MEASUREMENT AND IMPLICATION SERUM IMMUNOGLOBULINS AND PERIPHERALTLYMPHOCYTE SUBSETS IN PATIENTS WITH HEPATIC DISORDERS

作　　者：王超[1] 高志红[1] 贾红玲[2] 

机构地区：[1]大连医科大学附属第一医院消化科,辽宁大连116011 [2]牡丹江医学院红旗医院内科,黑龙江牡丹江157000

出　　处：《医师进修杂志》2002年第8期21-22,共2页Journal of Postgraduates of Medicine

摘　　要：目的　通过对不同肝病患者与正常对照组外周血清免疫球蛋白及T淋巴细胞亚群的检测 ,探讨肝病患者的机体免疫状态及临床意义。方法　选取正常对照组 2 0例 ,慢性乙型肝炎 1 8例 ,肝硬化 2 2例 ,肝癌 1 6例 ,取外周血测定血清免疫球蛋白水平及T淋巴细胞亚群。血清免疫球蛋白应用散射比浊法 ,T淋巴细胞亚群应用流式细胞仪检测。结果　与正常对照组相比 ,慢性肝炎、肝硬化组免疫球蛋白明显增高 (P <0 .0 5) ,肝癌组免疫球蛋白下降 (P<0 .0 5)。与正常对照组比较 ,慢性肝炎、肝硬化、肝癌的CD4 下降 (P <0 .0 5) ,CD8升高 (P <0 .0 5) ,CD4 /CD8比值明显降低 ,CD3略有下降。结论　肝病患者存在免疫功能紊乱 。Objective\ To evaluate the clinical implications of serum immunoglobulins and peripheral T-lymphocyte subsets in patients with various hepatic diseases.Methods\ Patient group including 18 patients with chronic type B viral hepatitis ,22 patients with liver cirrhosis,16 patients with hepatocarcinoma and 20 normal controls were measured for serum immunoglobulins level(by immune turbidimetry)and T-lymphocyte subsets (by flow cytometer).Results\ Compared with controls,the serum immunoglobulins levels were increased significantly in groups of chronic hepatitis and liver cirrhosis (P<0.05) and reduced in group of hepatocarcinoma (P<0.05).Compared with controls,in patients with chronic hepatitis,liver cirrhosis and hepatocarcinoma,the number of CD 4 cells was decreased (P<0.05), and CD 8 cells was increased (P<0.05), and the ratio between CD 4/CD 8 cells was decreased and the number of CD 3 cells was decreased slightly.Conclusions\ The immune function is disturbed in patients with hepatic diseases.It is meaningful to monitor the immune status in these patients to evaluate the development of hepatic disease.

关 键 词：慢性肝炎 肝硬化 肝癌 血清免疫球蛋白 T淋巴细胞亚群 免疫功能 

分 类 号：R512.6[医药卫生—内科学] R575.2[医药卫生—临床医学]