低强度脉冲超声治疗骨质疏松的可行性分析  

Feasibility analysis of low-intensity pulsed ultrasound treatment for osteoporosis

作　　者：李立荣[1] 孙舒心 他得安[1,2] 钦逸仙 王威琪[1] 

机构地区：[1]复旦大学电子工程系,上海200433 [2]上海市医学图像处理与计算机辅助手术重点实验室,上海200032 [3]Department of Biomedical Engineering,Stony Brook University

出　　处：《科学通报》2016年第26期2891-2900,共10页Chinese Science Bulletin

基　　金：国家杰出青年科学基金(11525416);国家自然科学基金(11174060;11327405);上海市科技支撑计划(13441901900)资助

摘　　要：骨质疏松症是一种全身性骨骼系统疾病,以骨量减少、骨微结构退化为主要特征,常伴有骨痛、驼背、骨折等症状,严重影响患者生活质量.目前骨质疏松治疗以药物治疗为主,但副作用较大.物理疗法低强度脉冲超声(LIPUS)则可以避免药物不良反应,且具有无创伤、无电离辐射等优点.研究表明,LIPUS刺激在骨折愈合中具有积极作用,而骨折和骨质疏松治疗时某些生物机制相似,因此LIPUS可能是治疗骨质疏松的重要潜在手段.本文通过查阅以"LIPUS"、"骨折"、"骨质疏松"为主题的大量相关资料并进行归纳总结,从骨组织结构与功能、LIPUS治疗骨病的生物学机制以及LIPUS治疗骨质疏松的实验研究入手,分析论证LIPUS治疗骨质疏松的有效依据,对LIPUS治疗骨质疏松研究现状进行综述,以期为治疗骨质疏松提供新的思路和理论依据.Osteoporosis is a musculoskeletal disease which is mainly characterized by bone loss and deterioration of bone microstructure, to which the middle-aged and elderly people are susceptible. It is often accompanied with bone pain, humpback, fractures and other symptoms, seriously affecting the quality of life of patients. As the population ages, osteoporosis incidence is increasing year by year, and currently these are approximately 200 million patients suffered from osteoporosis in the whole world. Furthermore, osteoporotic fracture has also caused great economic burden to families and society. On the other hand, in the weightless space environment, osteoporosis induced by unloading bones has become one of the important problems of astronauts＇ health, leading to impair their space exploration ability enhancement. Hence it is of great significance to its early diagnosis and timely treatment. Ultrasound as a therapeutic method has the advantage of low cost, non-invasive, non-ionizing radiation, fast and can be carried, and the findings in recent years show that ultrasonic backscatter signals can effectively reflect the micro-structure information of cancellous bone, therefore the evaluation of cancellous bone and diagnosis of osteoporosis with ultrasonic backscatter signal has become a focus. And clinical evaluation of bone has made significant progress in adults and newborns. Currently, the main treatment of osteoporosis is drug therapy（common used drugs are bisphosphonates, calcium, vitamin D, calcitonin, estrogen）. Drug therapy typically has systemic effects along with side effects, however. Physical therapy such as ultrasound, magnetic therapy and hyperthermia is able to avoid the adverse effect of drug therapy. Low-intensity pulsed ultrasound（LIPUS） has been proved to be an effective mechanical signal to bone tissue and it is used to the treatment of orthopedic diseases, which can play its mechanical effect and avoid the damage of thermal effect to the tissue cells. Study in recent years has demonstrat

关 键 词：骨质疏松 低强度脉冲超声 骨折 生物学机制 

分 类 号：R580[医药卫生—内分泌] TB559[医药卫生—内科学]