抗菌肽与肠道健康研究新进展  

Progress in studying antimicrobial peptides and intestinal health

作　　者：刘伟[1] 皮雄娥[1] 王欣[1] Wei Liu Xiong＇e Pi Xin Wang(Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, Zhejiang Province, China)

机构地区：[1]浙江省农业科学院植物保护与微生物研究所,浙江杭州310021

出　　处：《微生物学报》2016年第10期1537-1543,共7页Acta Microbiologica Sinica

基　　金：浙江省公益性项目(2014C32G4010031);国家"863计划"(2015AA020701);浙江省植物有害生物防控重点实验室-省部共建国家重点实验室培育基地(2010DS700124-ZZ1604)~~

摘　　要：抗菌肽是生物体内诱导产生的一类具有抗菌作用的生物活性肽,在机体抵抗病原入侵方面起着重要作用。近年来,肠道微生态研究炙手可热,抗菌肽与肠道健康的研究正广泛开展。相关研究结果表明,抗菌肽表达水平的高低可以用来评估机体肠道健康状态,从而监测抗菌肽表达水平来建立一种疾病预防和治疗过程中的辅助诊断手段。本文围绕抗菌肽对肠道菌群结构和免疫影响两方面的最新研究进展进行归纳与分析,旨在为临床诊断与治疗提供参考。Antimicrobial peptides （AMPs） are bioactive short peptides produced in organisms. AMPs have important roles in resisting pathogen invasion. In recent years, several studies on intestinal microecology is hot and the influence of antimicrobial peptides on intestinal health is widely concerned. Relevant results have demonstrated that the expression level of AMPs can be used to assess the body＇s intestinal health, thereby an auxiliary method could be established through monitoring on the expression level of AMPs during disease prevention and treatment. In this paper, research advances in antimicrobial peptides in intestinal microflora structure and immune effect were summarized and analyzed to provide references for clinical diagnosis and treatment.

关 键 词：抗菌肽 肠道稳态 肠道微生物 

分 类 号：R3411[医药卫生—基础医学]