环氧化酶-2抑制剂依托考昔治疗急性痛风性关节炎的疗效和安全性分析  

Analysis of the clinical effect and safety of cyclooxygenase-2(COX-2) inhibitors of etoricoxib in treatment of acute gout arthritis

作　　者：李善敬 陈玲 陈艳 陈庞何 苏成标 

机构地区：[1]广东省湛江市第二人民医院急诊科,广东湛江524003

出　　处：《吉林医学》2016年第10期2447-2448,共2页Jilin Medical Journal

摘　　要：目的:探讨环氧化酶-2抑制剂依托考昔治疗急性痛风性关节炎的疗效和安全性。方法:选择收治的急性痛风性关节炎患者94例作为研究对象,根据治疗方式的不同随机将患者分为对照组(47例)和观察组(47例),对照组给予患者双氯芬酸钠治疗,观察组给予患者依托考昔治疗。观察两组患者治疗效果。结果:观察组各项指标显著优于对照组,差异有统计学意义(P<0.05);两组患者治疗后疼痛评分均下降,观察组疼痛评分显著优于对照组,差异有统计学意义(P<0.05)。结论:环氧化酶-2抑制剂依托考昔治疗急性痛风性关节炎的疗效佳,安全可靠。Objective To probe into the clinical effects and safety of cyclooxygenase- 2（ COX- 2） inhibitors of etoricoxib in treatment of acute gout arthritis. Method 94 patients with acute gout arthritis who accepted treatments were taken as the research objects,and these patients were randomly divided into the control group（ 47 cases） and the observation group（ 47 cases）according to the different treatment methods. In the control group,they were given diclofenac sodium treatment while in the observation group,they were treated with the etoricoxib. Then,the treatment effects of these two groups of patients were compared. Results The indexes in the observation group were significantly better than those of the control group,the difference was statistically significant（ P〈0. 05）; After the treatment,the pain scores of the two groups were decreased,and the pain score of the observation group was significantly better than that of the control group,the difference was statistically significant（ P〈0. 05）. Conclusion The clinical effects of yclooxygenase- 2（ COX- 2） inhibitors of etoricoxib in treatment of acute gout arthritis are good enough,and it is safety and reliable.

关 键 词：依托考昔 急性痛风性关节炎 安全性 

分 类 号：R589.7[医药卫生—内分泌]