胰岛素泵治疗对不同BMI酮症起病的2型糖尿病患者胰岛功能的影响  

Effects of insulin pump treatment on beta cell function in patients with ketosis-onset diabetes about the different body mass index

作　　者：陈振新 李素梅 林国新 陈金星 姚奇棋 

机构地区：[1]福建省莆田市第一医院内分泌科,福建莆田351100

出　　处：《吉林医学》2016年第10期2472-2474,共3页Jilin Medical Journal

摘　　要：目的:探讨胰岛素泵治疗对不同BMI的酮症起病的2型糖尿病患者胰岛功能的影响。方法:选择酮症起病的2型糖尿病患者50例,以BMI 24 kg/m2为界,分为肥胖组28例和非肥胖组22例,均采用胰岛素泵强化治疗2周,并随访15周。应用稳态模型评估胰岛素抵抗指数和胰岛β细胞功能。观察患者治疗前、治疗后2周、治疗后15周胰岛素抵抗指数和胰岛β细胞功能的变化。结果:治疗前肥胖组与非肥胖组胰岛功能差异无统计学意义(P>0.05);治疗后两组胰岛功能均有明显改善(P<0.05),肥胖组较非肥胖组改善更明显(P<0.05),差异有统计学意义。结论:胰岛素泵强化治疗能显著改善酮症起病的2型糖尿病患者的胰岛功能,减轻胰岛素抵抗,尤其肥胖患者胰岛功能改善更明显。Objective To evaluate the influence of the insulin pump treatment on beta cell function in patients with ketosis-onset diabetes about the different body mass index. Method Fifty inpatients with ketosis- onset diabetes were divided into two groups such as the obesity group（ n = 28） and the Non- obesity group（ n = 22）,according to the body mass index lim it 24 kg /m^2. All patientsw ere treated by insulin pump for two weeks. HOMA- IR and HOMA- β were used to estimate insulin sensitivity and β- cell function respectively on three separate occasions. The occasions were the visits before trestment,after 2 weeks and after 15 weeks. Results There was no obviously differences in the beta cell function between two groups before treatment,the difference was not statistically significant（ P〉0. 05）. After treatments,both the beta cell functions of two groups were improved significantly,the difference was statistically significant（ P〈0. 05）,the beta cell functions of the obesity group were improved significantly,compared to the Non- obesity group,the difference was statistically significant（ P〈0. 05）. Conclusion The beta cell functions of both groups is improved after the treatments of insulin pump,the Obesity group is improved significantly.

关 键 词：体重指数 糖尿病 酮症 胰岛功能 

分 类 号：R587.1[医药卫生—内分泌]