血清HBsAg阳性肾小球肾炎的临床与病理分析  

Analysis of Clinical Features and Pathology of Serum HBsAg Positive Glomerulonephritis

作　　者：谢婷婷[1] 彭涛[1] 刘蕾[1] 甄军晖[2] 杨向东[1] 

机构地区：[1]山东大学齐鲁医院肾内科,山东济南250012 [2]山东大学齐鲁医院病理科,山东济南250012

出　　处：《医学与哲学（B）》2016年第8期51-53,共3页Medicine & Philosophy(B)

基　　金：2014年度山东省科技厅-科技发展计划(第一批);项目编号:2014GSF121005

摘　　要：分析血清HBsAg阳性肾炎患者发生乙型肝炎病毒相关性肾炎(HBV-GN)的相关因素。根据肾组织中是否检测到HBsAg和/或HBcAg将研究对象分为两组:HBV-GN组(30例)和乙型肝炎病毒合并肾炎(HBV-CG)组(26例),分析两组之间临床资料及病理特点。HBV-GN患者血清HBeAg的阳性率明显高于HBV-CG组(P<0.05),且HBV-GN组表现为大三阳[HBsAg(+)HBeAg(+)HBcAb(+)]的病例数明显多于HBV-CG组(21例vs.10例,P<0.05);HBV-GN组肾脏病理表现为微小病变肾病的病例数显著低于HBV-CG组(1例vs.7例,P<0.05)。HBV感染及病毒高复制状态与HBV-GN密切相关。To analyze of the factors related to the occurrence of HBV-GN in patients with serum HBsAg positive nephritis. According to the existence of HBsAg or HBcAg in renal tissues, patients were divided into two groups, Hepatitis B virus associated glomerulonephritis （HBV-GN group, 30 cases） and Hepatitis B virus infection complicated glomerulonephritis （HBV-CG group, 24 cases）. The differences of clinical features and pathological characteristics between two groups were analyzed. The rate of HBeAg positive in HBV-GN group was much higher than that in HBV-CG group （P〈0.05）. In addition, the number of patients with HBsAg（＋）HBeAg（＋）HBcAb（＋） in HBV-GN group was much higher than that in HBV-CG group patients（21 cases vs. 10 cases）（P〈0.05）. Moreover, the number of MCD patients diagnosed by renal biopsy in HBV-GN group was smaller than that in HBV-CG group（1 case vs. 7 cases）（P〈0.05）. HBV infection and high virus proliferation status are closely related with HBV-GN.

关 键 词：乙型肝炎病毒相关性肾炎 血清乙肝标志物 肾脏病理 

分 类 号：R692.6[医药卫生—泌尿科学]