针刺对大鼠胃肠肌间神经丛NO能神经元的影响  

Effect of Acupuncture on Nitroxidergic Neuron in Stomach and Intestine Intermuscular Nerve Plexus

作　　者：李瑞午[1] 李翠红[1] 郭莹[1] 葛文津[2] 夏立营[2] 

机构地区：[1]中国中医研究院针灸所,北京100700 [2]中国中医研究院西苑医院,北京100091

出　　处：《上海针灸杂志》2002年第4期40-42,共3页Shanghai Journal of Acupuncture and Moxibustion

基　　金：国家科委攀登计划"经络研究"项目资助课题

摘　　要：目的和方法　利用大鼠不规则进食的方法造成胃电节律失常的模型 ,模拟临床功能性消化不良的情况 ,通过针刺足三里和胃俞后观察胃肠肌间神经丛 NO能神经元数量和灰度的变化来研究针刺作用的机理。结果　针刺组与模型组相比神经元的密度下降 ,灰度值上升 ,而对上段小肠的影响不明显。结果　针刺足三里和胃俞穴可以使胃内 NOS的活性恢复到正常水平 ,有利于胃肠道功能的恢复。Purpose and Method To investigate the mechanism of acupuncture. The model of electrogastric dysrthythmias was made by feeding rat irregularly to simulate clinical functional indigestion. After acupuncturing Zusanli(ST36) and Weishu(BL21), the change of the quantity and the grey scale of nitroxidergic neuron in the stomach and intestine intermuscular nerve plexus were observed. Results The density of neuron in the acupuncture group is lower than that of model group, while the grey scale in the acupuncture group is higher than that of model group. The effect of acupuncture on the superior segment of intestine isn't significant. Conclusion Acupuncturing Zusanli(ST36) and Weishu(BL21) can recover the activity of nitroxide synthase(NOS) in stomach and restore the function of gastrointestinal tract.

关 键 词：针刺疗法 一氧化氮 NO 一氧化氮合酶 NOS 肠道神经系统 ENS 功能性消化不良 

分 类 号：R259.744[医药卫生—中西医结合] R246.1[医药卫生—中医内科学]