丝氨酸蛋白酶Corin在心血管疾病中的应用  

Corin-serine protease and clinical applications in cardiovascular disease

作　　者：韩雪晶[1] 贾克刚[1] 

机构地区：[1]泰达国际心血管病医院检验科天津医科大学心血管病临床学院,300457

出　　处：《中华检验医学杂志》2016年第9期661-664,共4页Chinese Journal of Laboratory Medicine

摘　　要：Corin是一种新兴的膜蛋白激酶，它可以使无活性的脑钠肽原转换成有活性的脑钠肽。而脑钠肽在调节血压和心脏功能方面发挥着重要作用，是心力衰竭的生物标志物。因此，Corin在降低血容量、血压、调节体液平衡，改善心功能方面发挥作用，很可能是心力衰竭或者其他心脏疾病的一种生物标志物。近几年研究发现，Corin与心力衰竭、急性冠状动脉综合征等心血管疾病的发生发展相关。在此，主要阐述Corin的生物学特性、检测方法及其在心血管疾病中的临床应用。Corin is a newly identified membrance protease which responsible for converting pro-B-type natriuretic peptide to biologically active B-type natriuretic peptide.B-type natriuretic peptide play an important role in regulating blood pressure and cardiac function.It is a biological marker of heart failure.So Corin plays a role in reducing blood volume, blood pressure, regulating body fluid balance, and improving cardiac function.Corin may be used as a biomarker for heart failure or other cardiovascular disease.Recent studies have found that Corin is associated with the occurrence and development of cardiovascular diseases, such as heart failure and acute coronary syndrome.The article mainly expound the biological characteristics of Corin, testing methods and its clinical application in cardiovascular disease status.

关 键 词：心力衰竭 心血管疾病 丝氨酸内肽酶类 生物学标记 

分 类 号：R54[医药卫生—心血管疾病] R446.1[医药卫生—内科学]