肾衰乙方治疗脾肾亏虚、浊毒瘀阻型慢性肾功能不全临床疗效及炎症机制研究  

Clinical Effects and Inflammation Mechanism on Renal Failure with Shenshuaiyi Decoction

作　　者：陈杰[1] 郑颖[1] 刘文瑞[1] 路建饶[1] 王新华[1] 陈秀峰[1] 胡静[1] 叶景华[1] 

机构地区：[1]上海市第七人民医院,上海200137

出　　处：《辽宁中医药大学学报》2016年第9期114-116,共3页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家中医药管理局"十二五"肾病重点专科建设项目;上海市科学技术委员会科研项目(15401934400);上海市浦东新区中医药事业发展专项资金项目(PDYNZJ2014-17)

摘　　要：目的:观察肾衰乙方对于脾肾亏虚、浊毒瘀阻型肾衰病的临床疗效以及炎症方面的作用机制。方法:将75例脾肾亏虚、浊毒瘀阻型肾衰病患者随机分为基础对照组、肾衰宁对照组和肾衰乙方治疗组,每组各25例,3组均给予基础治疗,肾衰宁对照组加用肾衰宁胶囊,肾衰乙方治疗组加用肾衰乙方,疗程1个月,观察治疗前后肌酐(SCr)、尿素氮(BUN)和炎症细胞因子转化生长因子(TGF-β1)、单核细胞趋化蛋白(MCP-1)和肿瘤坏死因子(TNF-α)的变化,并计算中医证候积分。结果:证候疗效上,基础对照组总有效率为64%,肾衰宁对照组总有效率为80%,肾衰乙方治疗组总有效率84%。实验室指标方面,与基础对照组相比,治疗后肾衰宁对照组、肾衰乙方治疗组的肌酐、尿素氮、转化生长因子、单核细胞趋化蛋白和肿瘤坏死因子均下降明显,且有显著性差异(P<0.01),但肾衰宁与肾衰乙方组之间相关指标无明显差异(P>0.05)。结论:肾衰乙方有改善脾肾亏虚、浊毒瘀阻型肾衰病患者临床症状,降低肌酐、尿素氮的作用,其机制与下调转化生长因子、单核细胞趋化蛋白和肿瘤坏死因子等炎症因子水平有关。Objective： To observe the clinical effects and the inflammation mechanism on renal failure with Shenshuaiyi Decoction. Methods ： The 75 renal failure patients were randomly divided into basic group, Shenshuaining Capsule control group and Shenshuaiyi Decoction treatment group （ 25 cases in each group ）. All the groups were given basic treatment, and Shenshuaining Capsule control group was treated additionanlly with Shenshuaining Capsule, and Shenshuaiyi Decoction group was treated additionanlly with Shenshuaiyi Decoction. After one month of treatment, the SCr, BUN, TGF-β1, MCP-1, TNF-α were observed. Results ： In the improvement of symptoms, treatment efficiency of the basic group, Shenshuaining Capsule control group and Shenshuaiyi Decoction treatment group respectively were 64%, 80% and 84%. Compared with the basic group, the SCr, BUN, TGF- β l, MCP-1, TNF- α of the Shenshuaining Capsule control group and Shenshuaiyi Decoction treatment group were reduced showing significant diference （ P〈0.01 ）. But between Shenshuaining Capsule control group and Shenshuaiyi Decoction treatment group, the result show no significant difference （ P〉0.05 ）. Conclusion ： Shenshuaiyi Decoction can improve the symptoms of the renal failure patients. Mechanism might be possibly correlated with it＇s down-regulation of its TGF- β 1, MCP-1, TNF- α levels.

关 键 词：肾衰乙方 肾衰病 炎症机制 

分 类 号：R692.5[医药卫生—泌尿科学]