Wnt信号通路与心脏发育和心肌诱导分化  

The role of Wnt signaling pathway in cardiac development and cardiac differentiation

作　　者：黄巧丽 周华[1] 李涛[1] 

机构地区：[1]浙江师范大学化学与生命科学学院,浙江金华321004

出　　处：《浙江师范大学学报（自然科学版）》2016年第3期331-337,共7页Journal of Zhejiang Normal University:Natural Sciences

基　　金：国家自然科学基金资助项目(31101057;31470082);浙江省自然科学基金资助项目(LY14C120001);浙江省公共创新平台实验动物项目(2014C37126)

摘　　要：Wnt信号通路是调控心肌细胞分化和心脏发育的重要信号通路.在哺乳动物中,迄今已发现19个分泌性Wnt蛋白,10个Frizzled受体和多个拮抗分子,显示Wnt信号家族效应广泛复杂.Wnt通路大致分为β-catenin依赖的经典通路和β-catenin非依赖的非经典通路,二者均在心脏发育中发挥重要的作用,广泛调控心肌细胞的增殖、分化、黏附、迁移和极化等.研究发现,Wnt信号通路在心肌细胞分化进程中存在明显的阶段特异性效应,呈现典型的双相性作用.通过小分子或转基因等调制Wnt信号通路,可有效提高体外多能干细胞向心肌的诱导分化效率.Wnt proteins had been shown to play multiple roles during cardiac differentiation and development. Until now, 19 Wnt ligands, 10 Frizzled receptors and several endogenous antagonists had been identified in mammals, suggested that the effect of Wnt signaling was immensely complicated. Wnt signaling were catego- rized into theβ-catenin dependent I canonical} , and β-catenin independent （non-canonical} pathways. Both signaling pathways played key roles in cardiac development, including cell division, differentiation, adhesion, migration, and polarity. Specifically, Wnt signaling exhibited biphasic effects on cardiac differentiation, depending on the stage of cardiomyogenesis. Therefore, modulating Wnt signaling manipulation would be a useful way to efficiently generate cardiomyocytes from by small molecules or genetic pluripotent stem cells.

关 键 词：WNT信号通路 心脏发育 心肌诱导分化 干细胞 

分 类 号：Q951[生物学—动物学]