康复新液对复发性口腔溃疡患者血清炎性因子表达的影响  

Effects of Kangfuxinye Liquid(康复新液) on the Serum Level of Inflammatory Cytokines in Recurrent Oral Ulcer

作　　者：温庆春[1] 罗毅[1] 李生柏[1] 陈雷[1] 

机构地区：[1]宜宾市第一人民医院,四川宜宾644000

出　　处：《中医药导报》2016年第19期83-84,90,共3页Guiding Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:研究康复新液对复发性口腔溃疡患者血清炎性因子及超氧化物歧化酶(SOD)表达水平的影响。方法:将136例复发性口腔溃疡患者随机分为治疗组和对照组,治疗组使用康复新液治疗,对照组使用复方氯己定含漱液治疗,疗程均为1周;观察比较两组总有效率、3个月内复发率、血清中炎性因子和SOD含量。结果:治疗后治疗组总有效率(91.2%)显著高于对照组(64.7%),差异有统计学意义(P<0.05);两组治疗后比较,治疗组患者溃疡时间及疼痛指数均低于对照组,差异有统计学意义(P<0.05);治疗后比较,治疗组血清中SOD、白介素-2(IL-2)浓度均高于对照组,肿瘤坏死因子-α(TNF-α)及白介素-8(IL-8)水平均低于对照组,差异均有统计学意义(P<0.05)。结论:康复新液治疗复发性口腔溃疡疗效显著,其机制可能与抑制炎性反应、氧化应激有关。Objective： To investigate the effects of Kangfuxinye liquid on serum level of inflammatory cytokines and superoxide dismutase （SOD） in recurrent oral ulcer. Methods： The 136 cases of patients with recurrent oral ulcer were randomly divided into control and treatment groups. Patients were treated by Kangfuxinye liquid in treatment group and Compound Gargle Solution Chlorhexidine Gluconate in control group; the treatment duration of two groups were 7 days. The total effective rates, recurrence rate within 3 months, serum inflammatory factors level and SOD concentration were compared between the two groups. Results： The total efficiency rate of treatment group （91.2%） was significantly higher than control group （64.7%） （P〈0.05）. After the treatment, the treatment group showed lower ulceration duration and pain index than the control group （P〈0.05）; the treatment group showed higher concentration of SOD and IL-2 than the control group, as well as lower concentration of TNF-α and IL-8 decreased than the control group, and the difference was statistically significant （P〈0.05）. Conclusion： Kangfuxinye liquid shows significant clinical effect on recurrent oral ulcer, the mechanism of which may be related to inhibition of inflammatory reaction and oxidant stress.

关 键 词：复发性口腔溃疡 康复新液 复发率 超氧化物歧化酶 炎性因子 

分 类 号：R276[医药卫生—中医五官科学]